El-Battrawy, Ibrahim, Cammann, Victoria L., Kato, Ken, Szawan, Konrad A., Di Vece, Davide, Rossi, Aurelio, Wischnewsky, Manfred, Hermes-Laufer, Julia, Gili, Sebastiano ORCID: 0000-0002-0542-0448, Citro, Rodolfo, Bossone, Eduardo, Neuhaus, Michael, Franke, Jennifer, Meder, Benjamin, Jaguszewski, Milosz, Noutsias, Michel, Knorr, Maike, Heiner, Susanne, D'Ascenzo, Fabrizio, Dichtl, Wolfgang, Burgdorf, Christof, Kherad, Behrouz, Tschoepe, Carsten, Sarcon, Annahita, Shinbane, Jerold, Rajan, Lawrence, Michels, Guido, Pfister, Roman, Cuneo, Alessandro, Jacobshagen, Claudius, Karakas, Mahir, Koenig, Wolfgang ORCID: 0000-0002-2064-9603, Pott, Alexander, Meyer, Philippe, Arroja, Jose David, Banning, Adrian, Cuculi, Florim, Kobza, Richard ORCID: 0000-0003-3988-7262, Fischer, Thomas A., Vasankari, Tuija, Airaksinen, K. E. Juhani, Napp, L. Christian, Budnik, Monika, Dworakowski, Rafal, MacCarthy, Philip, Kaiser, Christoph, Osswald, Stefan ORCID: 0000-0002-9240-6731, Galiuto, Leonarda, Chan, Christina, Bridgman, Paul, Beug, Daniel, Delmas, Clement, Lairez, Olivier, Gilyarova, Ekaterina, Shilova, Alexandra, Gilyarov, Mikhail, Kozel, Martin, Tousek, Petr, Winchester, David E., Galuszka, Jan, Ukena, Christian, Poglajen, Gregor, Carrilho-Ferreira, Pedro, Hauck, Christian, Paolini, Carla, Bilato, Claudio ORCID: 0000-0003-3474-0579, Kobayashi, Yoshio, Prasad, Abhiram, Rihal, Charanjit S., Liu, Kan, Schulze, P. Christian, Bianco, Matteo ORCID: 0000-0002-6751-6437, Joerg, Lucas, Rickli, Hans, Pestana, Goncalo, Nguyen, Thanh H., Boehm, Michael, Maier, Lars S., Pinto, Fausto J., Widimsky, Petr, Felix, Stephan B., Opolski, Grzegorz, Braun-Dullaeus, Ruediger C., Rottbauer, Wolfgang, Hasenfuss, Gerd, Pieske, Burkert M., Schunkert, Heribert, Thiele, Holger, Bauersachs, Johann, Katus, Hugo A., Horowitz, John D., Di Mario, Carlo, Muenzel, Thomas, Crea, Filippo ORCID: 0000-0002-9482-411X, Bax, Jeroen J., Luescher, Thomas F., Ruschitzka, Frank, Duru, Firat, Borggrefe, Martin, Ghadri, Jelena R., Akin, Ibrahim and Templin, Christian (2021). Impact of Atrial Fibrillation on Outcome in Takotsubo Syndrome: Data From the International Takotsubo Registry. J. Am. Heart Assoc., 10 (15). HOBOKEN: WILEY. ISSN 2047-9980

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Abstract

Background Atrial fibrillation (AF) is a major risk factor for mortality. The prevalence, clinical correlates, and prognostic impact of AF in Takotsubo syndrome (TTS) have not yet been investigated in a large patient cohort. This study aimed to investigate the prevalence, clinical correlates, and prognostic impact of AF in patients with TTS. Methods and Results Patients with TTS were enrolled from the International Takotsubo Registry, which is a multinational network with 26 participating centers in Europe and the United States. Patients were dichotomized according to the presence or absence of AF at the time of admission. Of 1584 patients with TTS, 112 (7.1%) had AF. The mean age was higher (P<0.001), and there were fewer women (P=0.046) in the AF than in the non-AF group. Left ventricular ejection fraction was significantly lower (P=0.001), and cardiogenic shock was more often observed (P<0.001) in the AF group. Both in-hospital (P<0.001) and long-term mortality (P<0.001) were higher in the AF group. Multivariable Cox regression analysis revealed that AF was independently associated with higher long-term mortality (hazard ratio, 2.31; 95% CI, 1.50-3.55; P<0.001). Among patients with AF on admission, 42% had no known history of AF before the acute TTS event, and such patients had comparable in-hospital and long-term outcomes compared with those with a history of AF. Conclusions In patients presenting with TTS, AF on admission is significantly associated with increased in-hospital and long-term mortality rates. Whether antiarrhythmics and/or cardioversion are beneficial in TTS with AF should thus be tested in a future trial. Registration URL: ; Unique identifier: NCT01947621.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
El-Battrawy, IbrahimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cammann, Victoria L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kato, KenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Szawan, Konrad A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Di Vece, DavideUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rossi, AurelioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wischnewsky, ManfredUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hermes-Laufer, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gili, SebastianoUNSPECIFIEDorcid.org/0000-0002-0542-0448UNSPECIFIED
Citro, RodolfoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bossone, EduardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neuhaus, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franke, JenniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meder, BenjaminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaguszewski, MiloszUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noutsias, MichelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knorr, MaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heiner, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
D'Ascenzo, FabrizioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dichtl, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burgdorf, ChristofUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kherad, BehrouzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tschoepe, CarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarcon, AnnahitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shinbane, JeroldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rajan, LawrenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michels, GuidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfister, RomanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuneo, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jacobshagen, ClaudiusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karakas, MahirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, WolfgangUNSPECIFIEDorcid.org/0000-0002-2064-9603UNSPECIFIED
Pott, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arroja, Jose DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Banning, AdrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuculi, FlorimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kobza, RichardUNSPECIFIEDorcid.org/0000-0003-3988-7262UNSPECIFIED
Fischer, Thomas A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vasankari, TuijaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Airaksinen, K. E. JuhaniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Napp, L. ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Budnik, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dworakowski, RafalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
MacCarthy, PhilipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaiser, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Osswald, StefanUNSPECIFIEDorcid.org/0000-0002-9240-6731UNSPECIFIED
Galiuto, LeonardaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chan, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bridgman, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beug, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delmas, ClementUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lairez, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gilyarova, EkaterinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shilova, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gilyarov, MikhailUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kozel, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tousek, PetrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winchester, David E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Galuszka, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ukena, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poglajen, GregorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carrilho-Ferreira, PedroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hauck, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paolini, CarlaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bilato, ClaudioUNSPECIFIEDorcid.org/0000-0003-3474-0579UNSPECIFIED
Kobayashi, YoshioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prasad, AbhiramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rihal, Charanjit S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liu, KanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulze, P. ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bianco, MatteoUNSPECIFIEDorcid.org/0000-0002-6751-6437UNSPECIFIED
Joerg, LucasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rickli, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pestana, GoncaloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nguyen, Thanh H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boehm, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, Lars S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pinto, Fausto J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Widimsky, PetrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Felix, Stephan B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Opolski, GrzegorzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Braun-Dullaeus, Ruediger C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rottbauer, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hasenfuss, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pieske, Burkert M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schunkert, HeribertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thiele, HolgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauersachs, JohannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katus, Hugo A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horowitz, John D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Di Mario, CarloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muenzel, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crea, FilippoUNSPECIFIEDorcid.org/0000-0002-9482-411XUNSPECIFIED
Bax, Jeroen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luescher, Thomas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruschitzka, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duru, FiratUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borggrefe, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghadri, Jelena R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Akin, IbrahimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Templin, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-608246
DOI: 10.1161/JAHA.119.014059
Journal or Publication Title: J. Am. Heart Assoc.
Volume: 10
Number: 15
Date: 2021
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 2047-9980
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MECHANOELECTRIC FEEDBACK; CARDIOMYOPATHY; INFARCTION; PROGNOSIS; EVENTSMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60824

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