Serinol: small molecule - big impact
The amino alcohol serinol (2-amino-1,3-propanediol) has become a common intermediate for several chemical processes. Since the 1940s serinol was used as precursor for synthesis of synthetic antibiotics (chloramphenicol). In the last years, new scopes of applications were discovered. Serinol is used...
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| FB/Einrichtung: | FB 13: Biologie |
| Dokumenttypen: | Artikel |
| Medientypen: | Text |
| Erscheinungsdatum: | 2011 |
| Publikation in MIAMI: | 06.11.2013 |
| Datum der letzten Änderung: | 21.01.2020 |
| Angaben zur Ausgabe: | [Electronic ed.] |
| Quelle: | AMB Express 1 (2011) 12 |
| Schlagwörter: | 2-Amino-1, 3-propanediol, Amino alcohol, Serinol |
| Fachgebiet (DDC): | 570: Biowissenschaften; Biologie |
| Rechtlicher Vermerk: | Die folgenden Lizenzbestimmungen sind mit dieser Ressource verbunden: Creative Commons Lizenz (CC BY 2.0) http://creativecommons.org/licenses/by/2.0/ |
| Lizenz: | CC BY 2.0 |
| Sprache: | English |
| Anmerkungen: | Finanziert durch den Open-Access-Publikationsfonds 2011/2012 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster). |
| Format: | PDF-Dokument |
| URN: | urn:nbn:de:hbz:6-05329435744 |
| Weitere Identifikatoren: | DOI: 10.1186/2191-0855-1-12 |
| Permalink: | https://nbn-resolving.de/urn:nbn:de:hbz:6-05329435744 |
| Onlinezugriff: | 2191-0855-1-12.pdf |
The amino alcohol serinol (2-amino-1,3-propanediol) has become a common intermediate for several chemical processes. Since the 1940s serinol was used as precursor for synthesis of synthetic antibiotics (chloramphenicol). In the last years, new scopes of applications were discovered. Serinol is used for X-ray contrast agents, pharmaceuticals or for chemical sphingosine/ceramide synthesis. It can either be obtained by chemical processes based on 2-nitro-1,3-propanediol, dihydroxyacetone and ammonia, dihydroxyacetone oxime or 5-amino-1,3- dioxane, or biotechnological application of amino alcohol dehydrogenases (AMDH) or transaminases. This review provides a survey of synthesis, properties and applications for serinol.