Surprisingly high number of Twintrons in vertebrates
Twintrons represent a special intronic arrangement in which introns of two different types occupy the same gene position. Consequently, alternative splicing of these introns requires two different spliceosomes competing for the same RNA molecule. So far, only two twintrons have been described in ins...
| Verfasser: | |
|---|---|
| FB/Einrichtung: | FB 13: Biologie
FB 05: Medizinische Fakultät |
| Dokumenttypen: | Artikel |
| Medientypen: | Text |
| Erscheinungsdatum: | 2013 |
| Publikation in MIAMI: | 12.03.2013 |
| Datum der letzten Änderung: | 07.07.2021 |
| Angaben zur Ausgabe: | [Electronic ed.] |
| Quelle: | Biology Direct 8 (2013) 4 |
| Schlagwörter: | Twintrons; Vertebrate genomes; Gene expression |
| Fachgebiet (DDC): | 610: Medizin und Gesundheit |
| Lizenz: | CC BY 2.0 |
| Sprache: | English |
| Anmerkungen: | Finanziert durch den Open-Access-Publikationsfonds 2012/2013 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster). |
| Format: | PDF-Dokument |
| URN: | urn:nbn:de:hbz:6-87359538868 |
| Weitere Identifikatoren: | DOI: 10.1186/1745-6150-8-4 |
| Permalink: | https://nbn-resolving.de/urn:nbn:de:hbz:6-87359538868 |
| Onlinezugriff: | 1745-6150-8-4.pdf |
Twintrons represent a special intronic arrangement in which introns of two different types occupy the same gene position. Consequently, alternative splicing of these introns requires two different spliceosomes competing for the same RNA molecule. So far, only two twintrons have been described in insects. Surprisingly, we discovered several such arrangements in vertebrate genomes, which are quite conserved throughout the lineages. Reviewers: This article was reviewed by Fyodor Kondrashow and Eugene Koonin.