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Environmental management systems (EMS) require the assessment of environmental aspects to ensure that organizations recognize their most relevant impacts on the environment. The ecological scarcity method (ESM) provides weighting factors for environmental flows (pollutants and resources), called eco-factors (EF), applicable in the assessment of environmental aspects. EF are based on a distance-to-target approach, displaying the ratio of the current state to the respective policy targets for environmental flows. The ESM has been developed for Switzerland; however, for site-specific application beyond Switzerland, national EF are desirable. This publication presents a systematic procedure for the derivation of EF in an international framework, based on the investigation of eight countries worldwide and comprehensive data research. As a novel feature, the grouping of EF into sets is introduced, according to the character of the underlying policy target: legally based, intended policy, or expert recommendation. Overall, 134 EF for six environmental issues were calculated and applied in a case study from Volkswagen AG. An in-depth analysis identifies the differences between national EF and between sets of EF and discusses the implications for EMS. From the findings, general conclusions for future development and the application of EF in an international context of company management are derived.