@article{Plattner2006Globa-8491,
  year={2006},
  doi={10.1038/nature05230},
  title={Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia},
  number={7116},
  volume={444},
  issn={0028-0836},
  journal={Nature},
  pages={171--178},
  author={Plattner, Helmut and Aury, Jean-Marc and Jaillon, Olivier and Duret, Laurent and Noel, Benjamin and Jubin, Claire and Porcel, Betina M. and Ségurens, Béatrice and Daubin, Vincent and Anthouard, Véronique}
}

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    <dc:creator>Plattner, Helmut</dc:creator>
    <dc:creator>Duret, Laurent</dc:creator>
    <dc:contributor>Aury, Jean-Marc</dc:contributor>
    <dc:contributor>Noel, Benjamin</dc:contributor>
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    <dc:contributor>Porcel, Betina M.</dc:contributor>
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    <dc:creator>Ségurens, Béatrice</dc:creator>
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    <dc:creator>Noel, Benjamin</dc:creator>
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    <dc:creator>Aury, Jean-Marc</dc:creator>
    <dcterms:title>Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia</dcterms:title>
    <dc:contributor>Ségurens, Béatrice</dc:contributor>
    <dc:contributor>Daubin, Vincent</dc:contributor>
    <dcterms:issued>2006</dcterms:issued>
    <dc:creator>Daubin, Vincent</dc:creator>
    <dc:contributor>Jaillon, Olivier</dc:contributor>
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    <dcterms:abstract xml:lang="eng">The duplication of entire genomes has long been recognized as having great potential for evolutionary novelties, but the mechanisms underlying their resolution through gene loss are poorly understood. Here we show that in the unicellular eukaryote Paramecium tetraurelia, a ciliate, most of the nearly 40,000 genes arose through at least three successive whole-genome duplications. Phylogenetic analysis indicates that the most recent duplication coincides with an explosion of speciation events that gave rise to the P. aurelia complex of 15 sibling species. We observed that gene loss occurs over a long timescale, not as an initial massive event. Genes from the same metabolic pathway or protein complex have common patterns of gene loss, and highly expressed genes are over-retained after all duplications. The conclusion of this analysis is that many genes are maintained after whole-genome duplication not because of functional innovation but because of gene dosage constraints.</dcterms:abstract>
    <dc:rights>Attribution-NonCommercial-NoDerivs 2.0 Generic</dc:rights>
    <dc:creator>Porcel, Betina M.</dc:creator>
    <dc:creator>Jubin, Claire</dc:creator>
    <dc:creator>Jaillon, Olivier</dc:creator>
    <dcterms:bibliographicCitation>First publ. in: Nature 444 (2006), pp. 171-178</dcterms:bibliographicCitation>
    <dc:contributor>Plattner, Helmut</dc:contributor>
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