Comparative gene expression in toxic versus non-toxic strains of the marine dinoflagellate Alexandrium minutum
Yang I, John U, Beszteri S, Glöckner G, Krock B, Goesmann A, Cembella AD (2010)
BMC Genomics 11(1): 248.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Yang, Ines;
John, Uwe;
Beszteri, Sára;
Glöckner, Gernot;
Krock, Bernd;
Goesmann, AlexanderUniBi 
;
Cembella, Allan D.
;
Cembella, Allan D.Einrichtung
Abstract / Bemerkung
Background The dinoflagellate Alexandrium minutum typically produces paralytic shellfish poisoning (PSP) toxins, which are known only from cyanobacteria and dinoflagellates. While a PSP toxin gene cluster has recently been characterized in cyanobacteria, the genetic background of PSP toxin production in dinoflagellates remains elusive. Results We constructed and analysed an expressed sequence tag (EST) library of A. minutum, which contained 15,703 read sequences yielding a total of 4,320 unique expressed clusters. Of these clusters, 72% combined the forward-and reverse reads of at least one bacterial clone. This sequence resource was then used to construct an oligonucleotide microarray. We analysed the expression of all clusters in three different strains. While the cyanobacterial PSP toxin genes were not found among the A. minutum sequences, 192 genes were differentially expressed between toxic and non-toxic strains. Conclusions Based on this study and on the lack of identified PSP synthesis genes in the two existent Alexandrium tamarense EST libraries, we propose that the PSP toxin genes in dinoflagellates might be more different from their cyanobacterial counterparts than would be expected in the case of a recent gene transfer. As a starting point to identify possible PSP toxin-associated genes in dinoflagellates without relying on a priori sequence information, the sequences only present in mRNA pools of the toxic strain can be seen as putative candidates involved in toxin synthesis and regulation, or acclimation to intracellular PSP toxins.
Erscheinungsjahr
2010
Zeitschriftentitel
BMC Genomics
Band
11
Ausgabe
1
Art.-Nr.
248
ISSN
1471-2164
Page URI
https://pub.uni-bielefeld.de/record/1785504
Zitieren
Yang I, John U, Beszteri S, et al. Comparative gene expression in toxic versus non-toxic strains of the marine dinoflagellate Alexandrium minutum. BMC Genomics. 2010;11(1): 248.
Yang, I., John, U., Beszteri, S., Glöckner, G., Krock, B., Goesmann, A., & Cembella, A. D. (2010). Comparative gene expression in toxic versus non-toxic strains of the marine dinoflagellate Alexandrium minutum. BMC Genomics, 11(1), 248. https://doi.org/10.1186/1471-2164-11-248
Yang, Ines, John, Uwe, Beszteri, Sára, Glöckner, Gernot, Krock, Bernd, Goesmann, Alexander, and Cembella, Allan D. 2010. “Comparative gene expression in toxic versus non-toxic strains of the marine dinoflagellate Alexandrium minutum”. BMC Genomics 11 (1): 248.
Yang, I., John, U., Beszteri, S., Glöckner, G., Krock, B., Goesmann, A., and Cembella, A. D. (2010). Comparative gene expression in toxic versus non-toxic strains of the marine dinoflagellate Alexandrium minutum. BMC Genomics 11:248.
Yang, I., et al., 2010. Comparative gene expression in toxic versus non-toxic strains of the marine dinoflagellate Alexandrium minutum. BMC Genomics, 11(1): 248.
I. Yang, et al., “Comparative gene expression in toxic versus non-toxic strains of the marine dinoflagellate Alexandrium minutum”, BMC Genomics, vol. 11, 2010, : 248.
Yang, I., John, U., Beszteri, S., Glöckner, G., Krock, B., Goesmann, A., Cembella, A.D.: Comparative gene expression in toxic versus non-toxic strains of the marine dinoflagellate Alexandrium minutum. BMC Genomics. 11, : 248 (2010).
Yang, Ines, John, Uwe, Beszteri, Sára, Glöckner, Gernot, Krock, Bernd, Goesmann, Alexander, and Cembella, Allan D. “Comparative gene expression in toxic versus non-toxic strains of the marine dinoflagellate Alexandrium minutum”. BMC Genomics 11.1 (2010): 248.
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Zhang H, Hou Y, Miranda L, Campbell DA, Sturm NR, Gaasterland T, Lin S., Proc. Natl. Acad. Sci. U.S.A. 104(11), 2007
PMID: 17360573
Zhang H, Hou Y, Miranda L, Campbell DA, Sturm NR, Gaasterland T, Lin S., Proc. Natl. Acad. Sci. U.S.A. 104(11), 2007
PMID: 17360573
Spliced leader RNA-mediated trans-splicing in a dinoflagellate, Karenia brevis.
Lidie KB, van Dolah FM., J. Eukaryot. Microbiol. 54(5), 2007
PMID: 17910687
Lidie KB, van Dolah FM., J. Eukaryot. Microbiol. 54(5), 2007
PMID: 17910687
Nuclear-encoded, plastid-targeted genes suggest a single common origin for apicomplexan and dinoflagellate plastids.
Fast NM, Kissinger JC, Roos DS, Keeling PJ., Mol. Biol. Evol. 18(3), 2001
PMID: 11230543
Fast NM, Kissinger JC, Roos DS, Keeling PJ., Mol. Biol. Evol. 18(3), 2001
PMID: 11230543
Dinoflagellates come from outer space but haptophytes and diatoms do not
AUTHOR UNKNOWN, 2004
AUTHOR UNKNOWN, 2004
From stop to start: tandem gene arrangement, copy number and trans-splicing sites in the dinoflagellate Amphidinium carterae.
Bachvaroff TR, Place AR., PLoS ONE 3(8), 2008
PMID: 18698341
Bachvaroff TR, Place AR., PLoS ONE 3(8), 2008
PMID: 18698341
Topology of splicing and snRNP biogenesis in dinoflagellate nuclei.
Alverca E, Franca S, Diaz de la Espina SM., Biol. Cell 98(12), 2006
PMID: 16875467
Alverca E, Franca S, Diaz de la Espina SM., Biol. Cell 98(12), 2006
PMID: 16875467
Chemical and enzymatic transformation of paralytic shellfish toxins in marine organisms
AUTHOR UNKNOWN, 1995
AUTHOR UNKNOWN, 1995
A sulfotransferase specific to N-21 of gonyautoxin 2/3 from crude enzyme extraction of toxic dinoflagellate Alexandrium tamarense CI01
AUTHOR UNKNOWN, 2007
AUTHOR UNKNOWN, 2007
Purification and characterization of sulfotransferase specific to O-22 of 11-hydroxy saxitoxin from the toxic dinoflagellate Gymnodinium catenatum (Dinophyceae)
AUTHOR UNKNOWN, 2002
AUTHOR UNKNOWN, 2002
Evolution of filamentous plant pathogens: gene exchange across eukaryotic kingdoms.
Richards TA, Dacks JB, Jenkinson JM, Thornton CR, Talbot NJ., Curr. Biol. 16(18), 2006
PMID: 16979565
Richards TA, Dacks JB, Jenkinson JM, Thornton CR, Talbot NJ., Curr. Biol. 16(18), 2006
PMID: 16979565
Initial sequencing and analysis of the human genome.
Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C, Stange-Thomann Y, Stojanovic N, Subramanian A, Wyman D, Rogers J, Sulston J, Ainscough R, Beck S, Bentley D, Burton J, Clee C, Carter N, Coulson A, Deadman R, Deloukas P, Dunham A, Dunham I, Durbin R, French L, Grafham D, Gregory S, Hubbard T, Humphray S, Hunt A, Jones M, Lloyd C, McMurray A, Matthews L, Mercer S, Milne S, Mullikin JC, Mungall A, Plumb R, Ross M, Shownkeen R, Sims S, Waterston RH, Wilson RK, Hillier LW, McPherson JD, Marra MA, Mardis ER, Fulton LA, Chinwalla AT, Pepin KH, Gish WR, Chissoe SL, Wendl MC, Delehaunty KD, Miner TL, Delehaunty A, Kramer JB, Cook LL, Fulton RS, Johnson DL, Minx PJ, Clifton SW, Hawkins T, Branscomb E, Predki P, Richardson P, Wenning S, Slezak T, Doggett N, Cheng JF, Olsen A, Lucas S, Elkin C, Uberbacher E, Frazier M, Gibbs RA, Muzny DM, Scherer SE, Bouck JB, Sodergren EJ, Worley KC, Rives CM, Gorrell JH, Metzker ML, Naylor SL, Kucherlapati RS, Nelson DL, Weinstock GM, Sakaki Y, Fujiyama A, Hattori M, Yada T, Toyoda A, Itoh T, Kawagoe C, Watanabe H, Totoki Y, Taylor T, Weissenbach J, Heilig R, Saurin W, Artiguenave F, Brottier P, Bruls T, Pelletier E, Robert C, Wincker P, Smith DR, Doucette-Stamm L, Rubenfield M, Weinstock K, Lee HM, Dubois J, Rosenthal A, Platzer M, Nyakatura G, Taudien S, Rump A, Yang H, Yu J, Wang J, Huang G, Gu J, Hood L, Rowen L, Madan A, Qin S, Davis RW, Federspiel NA, Abola AP, Proctor MJ, Myers RM, Schmutz J, Dickson M, Grimwood J, Cox DR, Olson MV, Kaul R, Raymond C, Shimizu N, Kawasaki K, Minoshima S, Evans GA, Athanasiou M, Schultz R, Roe BA, Chen F, Pan H, Ramser J, Lehrach H, Reinhardt R, McCombie WR, de la Bastide M, Dedhia N, Blocker H, Hornischer K, Nordsiek G, Agarwala R, Aravind L, Bailey JA, Bateman A, Batzoglou S, Birney E, Bork P, Brown DG, Burge CB, Cerutti L, Chen HC, Church D, Clamp M, Copley RR, Doerks T, Eddy SR, Eichler EE, Furey TS, Galagan J, Gilbert JG, Harmon C, Hayashizaki Y, Haussler D, Hermjakob H, Hokamp K, Jang W, Johnson LS, Jones TA, Kasif S, Kaspryzk A, Kennedy S, Kent WJ, Kitts P, Koonin EV, Korf I, Kulp D, Lancet D, Lowe TM, McLysaght A, Mikkelsen T, Moran JV, Mulder N, Pollara VJ, Ponting CP, Schuler G, Schultz J, Slater G, Smit AF, Stupka E, Szustakowki J, Thierry-Mieg D, Thierry-Mieg J, Wagner L, Wallis J, Wheeler R, Williams A, Wolf YI, Wolfe KH, Yang SP, Yeh RF, Collins F, Guyer MS, Peterson J, Felsenfeld A, Wetterstrand KA, Patrinos A, Morgan MJ, de Jong P, Catanese JJ, Osoegawa K, Shizuya H, Choi S, Chen YJ, Szustakowki J; International Human Genome Sequencing Consortium., Nature 409(6822), 2001
PMID: 11237011
Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C, Stange-Thomann Y, Stojanovic N, Subramanian A, Wyman D, Rogers J, Sulston J, Ainscough R, Beck S, Bentley D, Burton J, Clee C, Carter N, Coulson A, Deadman R, Deloukas P, Dunham A, Dunham I, Durbin R, French L, Grafham D, Gregory S, Hubbard T, Humphray S, Hunt A, Jones M, Lloyd C, McMurray A, Matthews L, Mercer S, Milne S, Mullikin JC, Mungall A, Plumb R, Ross M, Shownkeen R, Sims S, Waterston RH, Wilson RK, Hillier LW, McPherson JD, Marra MA, Mardis ER, Fulton LA, Chinwalla AT, Pepin KH, Gish WR, Chissoe SL, Wendl MC, Delehaunty KD, Miner TL, Delehaunty A, Kramer JB, Cook LL, Fulton RS, Johnson DL, Minx PJ, Clifton SW, Hawkins T, Branscomb E, Predki P, Richardson P, Wenning S, Slezak T, Doggett N, Cheng JF, Olsen A, Lucas S, Elkin C, Uberbacher E, Frazier M, Gibbs RA, Muzny DM, Scherer SE, Bouck JB, Sodergren EJ, Worley KC, Rives CM, Gorrell JH, Metzker ML, Naylor SL, Kucherlapati RS, Nelson DL, Weinstock GM, Sakaki Y, Fujiyama A, Hattori M, Yada T, Toyoda A, Itoh T, Kawagoe C, Watanabe H, Totoki Y, Taylor T, Weissenbach J, Heilig R, Saurin W, Artiguenave F, Brottier P, Bruls T, Pelletier E, Robert C, Wincker P, Smith DR, Doucette-Stamm L, Rubenfield M, Weinstock K, Lee HM, Dubois J, Rosenthal A, Platzer M, Nyakatura G, Taudien S, Rump A, Yang H, Yu J, Wang J, Huang G, Gu J, Hood L, Rowen L, Madan A, Qin S, Davis RW, Federspiel NA, Abola AP, Proctor MJ, Myers RM, Schmutz J, Dickson M, Grimwood J, Cox DR, Olson MV, Kaul R, Raymond C, Shimizu N, Kawasaki K, Minoshima S, Evans GA, Athanasiou M, Schultz R, Roe BA, Chen F, Pan H, Ramser J, Lehrach H, Reinhardt R, McCombie WR, de la Bastide M, Dedhia N, Blocker H, Hornischer K, Nordsiek G, Agarwala R, Aravind L, Bailey JA, Bateman A, Batzoglou S, Birney E, Bork P, Brown DG, Burge CB, Cerutti L, Chen HC, Church D, Clamp M, Copley RR, Doerks T, Eddy SR, Eichler EE, Furey TS, Galagan J, Gilbert JG, Harmon C, Hayashizaki Y, Haussler D, Hermjakob H, Hokamp K, Jang W, Johnson LS, Jones TA, Kasif S, Kaspryzk A, Kennedy S, Kent WJ, Kitts P, Koonin EV, Korf I, Kulp D, Lancet D, Lowe TM, McLysaght A, Mikkelsen T, Moran JV, Mulder N, Pollara VJ, Ponting CP, Schuler G, Schultz J, Slater G, Smit AF, Stupka E, Szustakowki J, Thierry-Mieg D, Thierry-Mieg J, Wagner L, Wallis J, Wheeler R, Williams A, Wolf YI, Wolfe KH, Yang SP, Yeh RF, Collins F, Guyer MS, Peterson J, Felsenfeld A, Wetterstrand KA, Patrinos A, Morgan MJ, de Jong P, Catanese JJ, Osoegawa K, Shizuya H, Choi S, Chen YJ, Szustakowki J; International Human Genome Sequencing Consortium., Nature 409(6822), 2001
PMID: 11237011
Genome-wide analysis of redox-regulated genes in a dinoflagellate.
Okamoto OK, Hastings JW., Gene 321(), 2003
PMID: 14636994
Okamoto OK, Hastings JW., Gene 321(), 2003
PMID: 14636994
Cell cycle regulation in a dinoflagellate, Amphidinium operculatum: identification of the diel entraining cue and a possible role for cyclic AMP.
Leighfield TA, Van Dolah FM., J. Exp. Mar. Biol. Ecol. 262(2), 2001
PMID: 11445086
Leighfield TA, Van Dolah FM., J. Exp. Mar. Biol. Ecol. 262(2), 2001
PMID: 11445086
Cell cycle behavior of laboratory and field populations of the Florida red tide dinoflagellate, Karenia brevis
AUTHOR UNKNOWN, 2008
AUTHOR UNKNOWN, 2008
Cell division in the dinoflagellate Gamierdiscus toxicus is phased to the diurnal cycle and accompanied by activation of the cell cycle regulatory protein, CDC2 kinase
AUTHOR UNKNOWN, 1995
AUTHOR UNKNOWN, 1995
Evidence for cAMP-dependent protein kinase in the dinoflagellate, Amphidinium operculatum
AUTHOR UNKNOWN, 2002
AUTHOR UNKNOWN, 2002
Cell-cycle studies of the dinoflagellates Gonyaulax polyedra Stein and Gyrodinium uncatenum Hulburt during asexual and sexual reproduction
AUTHOR UNKNOWN, 1990
AUTHOR UNKNOWN, 1990
LIFE HISTORY AND IN SITU GROWTH RATES OF ALEXANDRIUM TAYLORI (DINOPHYCEAE, PYRROPHYTA)
Garces E, Delgado M, Maso M, Camp J., J. Phycol. 34(5), 1998
PMID: IND44478313
Garces E, Delgado M, Maso M, Camp J., J. Phycol. 34(5), 1998
PMID: IND44478313
Comparative Study of the Life Cycles of Alexandrium Tamutum and Alexandrium Minutum (Gonyaulacales, Dinophyceae) in Culture
Figueroa RI, Garces E, Bravo I., J. Phycol. 43(5), 2007
PMID: IND43955130
Figueroa RI, Garces E, Bravo I., J. Phycol. 43(5), 2007
PMID: IND43955130
Annotation of unknown yeast ORFs by correlation analysis of microarray data and extensive literature searches.
Pir P, Ulgen KO, Hayes A, Ilsen Onsan Z, Kirdar B, Oliver SG., Yeast 23(7), 2006
PMID: 16710832
Pir P, Ulgen KO, Hayes A, Ilsen Onsan Z, Kirdar B, Oliver SG., Yeast 23(7), 2006
PMID: 16710832
Genetic transformation of dinoflagellates (Amphidinium and Symbiodinium): expression of GUS in microalgae using heterologous promoter constructs
AUTHOR UNKNOWN, 1998
AUTHOR UNKNOWN, 1998
Cloning, sequencing and expression of dinoflagellate luciferase DNA from a marine alga, Gonyaulax polyedra.
Bae YM, Hastings JW., Biochim. Biophys. Acta 1219(2), 1994
PMID: 7918642
Bae YM, Hastings JW., Biochim. Biophys. Acta 1219(2), 1994
PMID: 7918642
C-terminal region of the active domain enhances enzymatic activity in dinoflagellate luciferase
AUTHOR UNKNOWN, 2008
AUTHOR UNKNOWN, 2008
Isolation of algal genes by functional complementation of yeast
AUTHOR UNKNOWN, 2002
AUTHOR UNKNOWN, 2002
An unusual S-adenosylmethionine synthetase gene from dinoflagellate is methylated.
Ho P, Kong KF, Chan YH, Tsang JS, Wong JT., BMC Mol. Biol. 8(), 2007
PMID: 17915037
Ho P, Kong KF, Chan YH, Tsang JS, Wong JT., BMC Mol. Biol. 8(), 2007
PMID: 17915037
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