@article{Owald2015Activ-30898,
  year={2015},
  doi={10.1016/j.neuron.2015.03.025},
  title={Activity of Defined Mushroom Body Output Neurons Underlies Learned Olfactory Behavior in Drosophila},
  url={http://www.sciencedirect.com/science/article/pii/S0896627315002214},
  number={2},
  volume={86},
  issn={0896-6273},
  journal={Neuron},
  pages={417--427},
  author={Owald, David and Felsenberg, Johannes and Talbot, Clifford B. and Das, Gaurav and Perisse, Emmanuel and Huetteroth, Wolf and Waddell, Scott}
}

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    <dc:creator>Das, Gaurav</dc:creator>
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    <dc:contributor>Talbot, Clifford B.</dc:contributor>
    <dc:contributor>Waddell, Scott</dc:contributor>
    <dc:contributor>Owald, David</dc:contributor>
    <dc:creator>Talbot, Clifford B.</dc:creator>
    <dc:contributor>Perisse, Emmanuel</dc:contributor>
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    <dcterms:abstract xml:lang="eng">During olfactory learning in fruit flies, dopaminergic neurons assign value to odor representations in the mushroom body Kenyon cells. Here we identify a class of downstream glutamatergic mushroom body output neurons (MBONs) called M4/6, or MBON-β2β'2a, MBON-β'2mp, and MBON-γ5β'2a, whose dendritic fields overlap with dopaminergic neuron projections in the tips of the β, β', and γ lobes. This anatomy and their odor tuning suggests that M4/6 neurons pool odor-driven Kenyon cell synaptic outputs. Like that of mushroom body neurons, M4/6 output is required for expression of appetitive and aversive memory performance. Moreover, appetitive and aversive olfactory conditioning bidirectionally alters the relative odor-drive of M4β' neurons (MBON-β'2mp). Direct block of M4/6 neurons in naive flies mimics appetitive conditioning, being sufficient to convert odor-driven avoidance into approach, while optogenetically activating these neurons induces avoidance behavior. We therefore propose that drive to the M4/6 neurons reflects odor-directed behavioral choice.</dcterms:abstract>
    <dcterms:issued>2015</dcterms:issued>
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    <dc:creator>Felsenberg, Johannes</dc:creator>
    <dc:creator>Owald, David</dc:creator>
    <dc:contributor>Das, Gaurav</dc:contributor>
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    <dcterms:title>Activity of Defined Mushroom Body Output Neurons Underlies Learned Olfactory Behavior in Drosophila</dcterms:title>
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    <dc:creator>Perisse, Emmanuel</dc:creator>
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