Systems Toxicology : The Future of Risk Assessment

Lade...
Vorschaubild
Dateien
Sauer_0-291326.pdf
Sauer_0-291326.pdfGröße: 90.85 KBDownloads: 183
Datum
2015
Autor:innen
Sauer, John Michael
Knudsen, Thomas B
Hoeng, Julia
Hayes, A. Wallace
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Green
Sammlungen
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
International Journal of Toxicology. 2015, 34(4), pp. 346-348. ISSN 0730-0913. eISSN 1092-874X. Available under: doi: 10.1177/1091581815576551
Zusammenfassung

Risk assessment, in the context of public health, is the process of quantifying the probability of a harmful effect to individuals or populations from human activities. With increasing public health concern regarding the potential risks associated with chemical exposure, there is a need for more predictive and accurate approaches to risk assessment. Developing such an approach requires a mechanistic understanding of the process by which xenobiotic substances perturb biological systems and lead to toxicity. Supplementing the shortfalls of traditional risk assessment with mechanistic biological data has been widely discussed but not routinely implemented in the evaluation of chemical exposure. These mechanistic approaches to risk assessment have been generally referred to as systems toxicology. This Symposium Overview article summarizes 4 talks presented at the 35th Annual Meeting of the American College of Toxicology.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690SAUER, John Michael, Thomas HARTUNG, Marcel LEIST, Thomas B KNUDSEN, Julia HOENG, A. Wallace HAYES, 2015. Systems Toxicology : The Future of Risk Assessment. In: International Journal of Toxicology. 2015, 34(4), pp. 346-348. ISSN 0730-0913. eISSN 1092-874X. Available under: doi: 10.1177/1091581815576551
BibTex
@article{Sauer2015-07Syste-31068,
  year={2015},
  doi={10.1177/1091581815576551},
  title={Systems Toxicology : The Future of Risk Assessment},
  number={4},
  volume={34},
  issn={0730-0913},
  journal={International Journal of Toxicology},
  pages={346--348},
  author={Sauer, John Michael and Hartung, Thomas and Leist, Marcel and Knudsen, Thomas B and Hoeng, Julia and Hayes, A. Wallace}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/31068">
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-06-01T08:03:08Z</dcterms:available>
    <dcterms:abstract xml:lang="eng">Risk assessment, in the context of public health, is the process of quantifying the probability of a harmful effect to individuals or populations from human activities. With increasing public health concern regarding the potential risks associated with chemical exposure, there is a need for more predictive and accurate approaches to risk assessment. Developing such an approach requires a mechanistic understanding of the process by which xenobiotic substances perturb biological systems and lead to toxicity. Supplementing the shortfalls of traditional risk assessment with mechanistic biological data has been widely discussed but not routinely implemented in the evaluation of chemical exposure. These mechanistic approaches to risk assessment have been generally referred to as systems toxicology. This Symposium Overview article summarizes 4 talks presented at the 35th Annual Meeting of the American College of Toxicology.</dcterms:abstract>
    <dc:contributor>Sauer, John Michael</dc:contributor>
    <dcterms:issued>2015-07</dcterms:issued>
    <dc:language>eng</dc:language>
    <dc:creator>Hoeng, Julia</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Hayes, A. Wallace</dc:creator>
    <dc:contributor>Hayes, A. Wallace</dc:contributor>
    <dc:creator>Knudsen, Thomas B</dc:creator>
    <dc:creator>Sauer, John Michael</dc:creator>
    <dc:rights>terms-of-use</dc:rights>
    <dc:contributor>Hartung, Thomas</dc:contributor>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/31068/1/Sauer_0-291326.pdf"/>
    <dc:contributor>Leist, Marcel</dc:contributor>
    <dc:creator>Leist, Marcel</dc:creator>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/31068/1/Sauer_0-291326.pdf"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Hoeng, Julia</dc:contributor>
    <dc:creator>Hartung, Thomas</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-06-01T08:03:08Z</dc:date>
    <dc:contributor>Knudsen, Thomas B</dc:contributor>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/31068"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:title>Systems Toxicology : The Future of Risk Assessment</dcterms:title>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Diese Publikation teilen