Hoxa2 Selects Barrelette Neuron Identity and Connectivity in the Mouse Somatosensory Brainstem

Bechara, Ahmad; Laumonnerie, Christophe; Vilain, Nathalie; Kratochwil, Claudius F.; Cankovic, Vanja; Maiorano, Nicola A.; Kirschmann, Moritz A.; Ducret, Sebastien; Rijli, Filippo M.

Hoxa2 Selects Barrelette Neuron Identity and Connectivity in the Mouse Somatosensory Brainstem

Dateien

Bechara_0-318546.pdfGröße: 5.85 MBDownloads: 613

Datum

2015

Autor:innen

Bechara, Ahmad

Laumonnerie, Christophe

Vilain, Nathalie

Kratochwil, Claudius F.

Cankovic, Vanja

Maiorano, Nicola A.

Kirschmann, Moritz A.

Ducret, Sebastien

Rijli, Filippo M.

Open Access-Veröffentlichung

Open Access Gold

Sammlungen

Biologie
Zukunftskolleg

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Cell Reports. 2015, 13(4), pp. 783-797. ISSN 2211-1247. eISSN 2211-1247. Available under: doi: 10.1016/j.celrep.2015.09.031

Zusammenfassung

Mouse whiskers are somatotopically mapped in brainstem trigeminal nuclei as neuronal modules known as barrelettes. Whisker-related afferents form barrelettes in ventral principal sensory (vPrV) nucleus, whereas mandibular input targets dorsal PrV (dPrV). How barrelette neuron identity and circuitry is established is poorly understood. We found that ectopic Hoxa2 expression in dPrV neurons is sufficient to attract whisker-related afferents, induce asymmetrical dendrite arbors, and allow ectopic barrelette map formation. Moreover, the thalamic area forming whisker-related barreloids is prenatally targeted by both vPrV and dPrV axons followed by perinatal large-scale pruning of dPrV axons and refinement of vPrV barrelette input. Ectopic Hoxa2 expression allows topographically directed targeting and refinement of dPrV axons with vPrV axons into a single whisker-related barreloid map. Thus, a single HOX transcription factor is sufficient to switch dPrV into a vPrV barrelette neuron program and coordinate input-output topographic connectivity of a dermatome-specific circuit module.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

BECHARA, Ahmad, Christophe LAUMONNERIE, Nathalie VILAIN, Claudius F. KRATOCHWIL, Vanja CANKOVIC, Nicola A. MAIORANO, Moritz A. KIRSCHMANN, Sebastien DUCRET, Filippo M. RIJLI, 2015. Hoxa2 Selects Barrelette Neuron Identity and Connectivity in the Mouse Somatosensory Brainstem. In: Cell Reports. 2015, 13(4), pp. 783-797. ISSN 2211-1247. eISSN 2211-1247. Available under: doi: 10.1016/j.celrep.2015.09.031

BibTex

@article{Bechara2015-10Hoxa2-33429,
  year={2015},
  doi={10.1016/j.celrep.2015.09.031},
  title={Hoxa2 Selects Barrelette Neuron Identity and Connectivity in the Mouse Somatosensory Brainstem},
  number={4},
  volume={13},
  issn={2211-1247},
  journal={Cell Reports},
  pages={783--797},
  author={Bechara, Ahmad and Laumonnerie, Christophe and Vilain, Nathalie and Kratochwil, Claudius F. and Cankovic, Vanja and Maiorano, Nicola A. and Kirschmann, Moritz A. and Ducret, Sebastien and Rijli, Filippo M.}
}

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Universitätsbibliographie

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