Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa
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Chemical Communications : ChemComm. 2016, 52(92), pp. 13440-13443. ISSN 0009-241X. eISSN 1364-548X. Available under: doi: 10.1039/c6cc06295d
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We explore the chemical space of Pseudomonas quinolone signal analogs as privileged structures and report the discovery of a thioquinolone as a potent inhibitor of the important virulence factor elastase of the human pathogen Pseudomonas aeruginosa. We provide evidence that the derivative binds to the active site zinc of elastase and additionally acts as a fluorescent zinc sensor.
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540 Chemie
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SZAMOSVARI, David, Valentin F. REICHLE, Monica JURESCHI, Thomas BĂ–TTCHER, 2016. Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa. In: Chemical Communications : ChemComm. 2016, 52(92), pp. 13440-13443. ISSN 0009-241X. eISSN 1364-548X. Available under: doi: 10.1039/c6cc06295dBibTex
@article{Szamosvari2016Synth-37585, year={2016}, doi={10.1039/c6cc06295d}, title={Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa}, number={92}, volume={52}, issn={0009-241X}, journal={Chemical Communications : ChemComm}, pages={13440--13443}, author={Szamosvari, David and Reichle, Valentin F. and Jureschi, Monica and Böttcher, Thomas} }
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