Interplay of hippocampal volume and hypothalamus-pituitary-adrenal axis function as markers of stress vulnerability in men at ultra-high risk for psychosis

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2017
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Bechard-Evans, Laura
Pira, Shamira
Joober, Ridha
Collins, D. Louis
Malla, Ashok K.
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Psychological Medicine. 2017, 47(03), pp. 471-483. ISSN 0033-2917. eISSN 1469-8978. Available under: doi: 10.1017/S0033291716002658
Zusammenfassung

Altered hypothalamus-pituitary-adrenal (HPA) axis function and reduced hippocampal volume (HV) are established correlates of stress vulnerability. We have previously shown an attenuated cortisol awakening response (CAR) and associations with HV specifically in male first-episode psychosis patients. Findings in individuals at ultra-high risk (UHR) for psychosis regarding these neurobiological markers are inconsistent, and assessment of their interplay, accounting for sex differences, could explain incongruent results.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
150 Psychologie
Schlagwörter
Cortisol, hippocampus, hypothalamus-pituitary-adrenal axis, sex differences, stress, ultra-high risk for psychosis
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ISO 690PRUESSNER, Marita, Laura BECHARD-EVANS, Shamira PIRA, Ridha JOOBER, D. Louis COLLINS, Jens C. PRUESSNER, Ashok K. MALLA, 2017. Interplay of hippocampal volume and hypothalamus-pituitary-adrenal axis function as markers of stress vulnerability in men at ultra-high risk for psychosis. In: Psychological Medicine. 2017, 47(03), pp. 471-483. ISSN 0033-2917. eISSN 1469-8978. Available under: doi: 10.1017/S0033291716002658
BibTex
@article{Pruessner2017-02Inter-38584,
  year={2017},
  doi={10.1017/S0033291716002658},
  title={Interplay of hippocampal volume and hypothalamus-pituitary-adrenal axis function as markers of stress vulnerability in men at ultra-high risk for psychosis},
  number={03},
  volume={47},
  issn={0033-2917},
  journal={Psychological Medicine},
  pages={471--483},
  author={Pruessner, Marita and Bechard-Evans, Laura and Pira, Shamira and Joober, Ridha and Collins, D. Louis and Pruessner, Jens C. and Malla, Ashok K.}
}
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