@article{Schoemaker2016Selec-38161,
  year={2016},
  doi={10.1016/j.dadm.2015.11.007},
  title={Selective familiarity deficits in otherwise cognitively intact aging individuals with genetic risk for Alzheimer's disease},
  volume={2},
  journal={Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring},
  pages={132--139},
  author={Schoemaker, Dorothee and Poirier, Judes and Escobar, Sophia and Gauthier, Serge and Pruessner, Jens C.}
}

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    <dc:contributor>Escobar, Sophia</dc:contributor>
    <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 International</dc:rights>
    <dcterms:issued>2016</dcterms:issued>
    <dc:creator>Pruessner, Jens C.</dc:creator>
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    <dcterms:title>Selective familiarity deficits in otherwise cognitively intact aging individuals with genetic risk for Alzheimer's disease</dcterms:title>
    <dc:contributor>Pruessner, Jens C.</dc:contributor>
    <dc:contributor>Gauthier, Serge</dc:contributor>
    <dc:contributor>Poirier, Judes</dc:contributor>
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    <dc:language>eng</dc:language>
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    <dc:creator>Schoemaker, Dorothee</dc:creator>
    <dc:creator>Gauthier, Serge</dc:creator>
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    <dcterms:abstract xml:lang="eng">Introduction&lt;br /&gt;&lt;br /&gt;Familiarity has been associated with integrity of the rhinal cortex. Thus, impairment in familiarity is expected in very early stages of Alzheimer's disease (AD). The apolipoprotein E (APOE) ε4 allele is a major risk factor for AD. Here, we investigated the effect of the APOE ε4 status on familiarity in cognitively normal aging individuals.&lt;br /&gt;&lt;br /&gt;Methods&lt;br /&gt;&lt;br /&gt;Eighty-one individuals aged between 55 and 80 years, 21 carriers and 60 noncarriers, were used in these analyses. A cognitive evaluation was performed on all participants to document the absence of objective cognitive deficits. The effect of APOE ε4 status on familiarity was tested using independent sample t test and an analysis of covariance controlling for age, gender, and education.&lt;br /&gt;&lt;br /&gt;Results&lt;br /&gt;&lt;br /&gt;The groups did not differ in term of age, education, and male/female ratio. APOE ε4 carriers showed a significant reduction in familiarity. No other cognitive deficit was observed in the group of ε4 carriers, relative to noncarriers.&lt;br /&gt;&lt;br /&gt;Discussion&lt;br /&gt;&lt;br /&gt;APOE ε4 is associated with a reduction in familiarity in the absence of other cognitive deficits. These results suggest that performance in familiarity could represent an early cognitive marker for individuals at risk of AD.</dcterms:abstract>
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    <dc:contributor>Schoemaker, Dorothee</dc:contributor>
    <dc:creator>Escobar, Sophia</dc:creator>
    <dc:creator>Poirier, Judes</dc:creator>
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