Separation of chiral colloidal particles in a helical flow field

Aristov, Maria; Eichhorn, Ralf; Bechinger, Clemens

Separation of chiral colloidal particles in a helical flow field

Dateien

Aristov_0-411280.pdfGröße: 340.69 KBDownloads: 530

Datum

2013

Autor:innen

Aristov, Maria

Eichhorn, Ralf

Bechinger, Clemens

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Physik

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Soft Matter. 2013, 9(8), pp. 2525-2530. ISSN 1744-683X. eISSN 1744-6848. Available under: doi: 10.1039/C2SM27441H

Zusammenfassung

Stereoisomeric molecules with opposite chirality, so-called enantiomers, often vary regarding their sensory, pharmacological and toxicological properties. Such enantiomer specific effects play a central role in the development, testing and evaluation of drugs, pesticides and food related products. Accordingly, efficient techniques for separation of chiral mixtures into enantiopure compounds are of enormous practical relevance. Most current enantiomer separation methods are based on enantioselective interactions with an auxiliary substance which has to be developed and optimized for different chiral molecules in an elaborate and costly process. Here, we experimentally demonstrate the separation of micron-sized chiral particles in a helical fluid flow which is created inside a microfluidic device patterned with slanted grooves. We observe that the retention time of particles in a helical flow field strongly depends on their chirality which leads to an effective chiral separation within the channel. Our experimental results are confirmed by numerical calculations which demonstrate how the coupling of rotational and translational degrees of freedom leads to differences in the trajectories of particles with opposite chirality. Since our separation mechanism does not rely on material specific interactions, this offers considerable advantages over existing methods. We expect that our approach can be also applied at nanometre length scales by using channels with smaller diameters and with an optimized geometry.

Fachgebiet (DDC)

530 Physik

Zitieren

ISO 690

ARISTOV, Maria, Ralf EICHHORN, Clemens BECHINGER, 2013. Separation of chiral colloidal particles in a helical flow field. In: Soft Matter. 2013, 9(8), pp. 2525-2530. ISSN 1744-683X. eISSN 1744-6848. Available under: doi: 10.1039/C2SM27441H

BibTex

@article{Aristov2013Separ-39286,
  year={2013},
  doi={10.1039/C2SM27441H},
  title={Separation of chiral colloidal particles in a helical flow field},
  number={8},
  volume={9},
  issn={1744-683X},
  journal={Soft Matter},
  pages={2525--2530},
  author={Aristov, Maria and Eichhorn, Ralf and Bechinger, Clemens}
}

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