Cytostatic factor : an activity that puts the cell cycle on hold

Schmidt, Andreas; Rauh, Nadine R.; Nigg, Erich A.; Mayer, Thomas U.

Cytostatic factor : an activity that puts the cell cycle on hold

Dateien

Mayer etal.pdfGröße: 238.33 KBDownloads: 355

Datum

2006

Autor:innen

Schmidt, Andreas

Rauh, Nadine R.

Nigg, Erich A.

Mayer, Thomas U.

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Journal of Cell Science. 2006, 119(7), pp. 1213-1218. ISSN 0021-9533. Available under: doi: 10.1242/jcs.02919

Zusammenfassung

Fertilization is the fundamental process in which two gametes - sperm and oocyte - fuse to generate a zygote that will form a new multicellular organism. In most vertebrates, oocytes await fertilization while arrested at metaphase of meiosis II. This resting state can be stable for many hours and depends on a cytoplasmic activity termed cytostatic factor (CSF). Recently, members of the novel Emi/Erp family of proteins have been put forward as important components of CSF. These proteins inhibit the anaphase-promoting complex/cyclosome (APC/C), which acts at the very core of the cell cycle regulatory machinery. Initially, Xenopus early mitotic inhibitor 1 (Emi1) was proposed to be a component of CSF, but newer work suggests that a structural relative, Emi-related protein 1 (Erp1/Emi2), is essential for maintenance of CSF arrest in Xenopus. Most importantly, studies on Erp1/Emi2 regulation have led to a detailed molecular understanding of the Ca2+-mediated release from CSF arrest that occurs upon fertilization.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

CSF, oocyte, egg, fertilization, Meiose Ubiquitin-Protein-Ligase

Zitieren

ISO 690

SCHMIDT, Andreas, Nadine R. RAUH, Erich A. NIGG, Thomas U. MAYER, 2006. Cytostatic factor : an activity that puts the cell cycle on hold. In: Journal of Cell Science. 2006, 119(7), pp. 1213-1218. ISSN 0021-9533. Available under: doi: 10.1242/jcs.02919

BibTex

@article{Schmidt2006-04-01Cytos-14043,
  year={2006},
  doi={10.1242/jcs.02919},
  title={Cytostatic factor : an activity that puts the cell cycle on hold},
  number={7},
  volume={119},
  issn={0021-9533},
  journal={Journal of Cell Science},
  pages={1213--1218},
  author={Schmidt, Andreas and Rauh, Nadine R. and Nigg, Erich A. and Mayer, Thomas U.}
}

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Universitätsbibliographie

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