@article{Zhang1997Unequ-14313,
  year={1997},
  doi={10.1084/jem.185.10.1837},
  title={Unequal Death in T Helper Cell (Th)1 and Th2 Effectors : Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis},
  number={10},
  volume={185},
  issn={0022-1007},
  journal={Journal of Experimental Medicine},
  pages={1837--1849},
  author={Zhang, Xiaohong and Brunner, Thomas and Carter, Laura and Dutton, Richard W. and Rogers, Paul and Bradley, Linda and Sato, Takaaki and Reed, John C. and Green, Douglas and Swain, Susan L.}
}

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    <dc:creator>Carter, Laura</dc:creator>
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    <dc:contributor>Reed, John C.</dc:contributor>
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    <dcterms:title>Unequal Death in T Helper Cell (Th)1 and Th2 Effectors : Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis</dcterms:title>
    <dcterms:bibliographicCitation>First publ. in: Journal of Experimental Medicine ; 185 (1997), 10. - pp. 1837-1849</dcterms:bibliographicCitation>
    <dc:creator>Reed, John C.</dc:creator>
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    <dc:contributor>Brunner, Thomas</dc:contributor>
    <dc:contributor>Rogers, Paul</dc:contributor>
    <dc:creator>Swain, Susan L.</dc:creator>
    <dc:creator>Zhang, Xiaohong</dc:creator>
    <dc:creator>Brunner, Thomas</dc:creator>
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    <dc:contributor>Zhang, Xiaohong</dc:contributor>
    <dc:contributor>Sato, Takaaki</dc:contributor>
    <dc:language>eng</dc:language>
    <dc:creator>Green, Douglas</dc:creator>
    <dc:contributor>Swain, Susan L.</dc:contributor>
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    <dc:creator>Dutton, Richard W.</dc:creator>
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    <dc:creator>Sato, Takaaki</dc:creator>
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    <dc:contributor>Carter, Laura</dc:contributor>
    <dcterms:abstract xml:lang="eng">T helper cell (Th) 1, but not Th2, effectors undergo rapid Fas/Fas ligand (FasL)-mediated, activation-induced cell death upon restimulation with antigen. Unequal apoptosis is also observed without restimulation, after a longer lag period. Both effectors undergo delayed apoptosis induced by a non–Fas-mediated pathway. When Th1 and Th2 effectors are co-cultured, Th2 effectors survive preferentially, suggesting the responsible factor(s) is intrinsic to each population. Both Th1 and Th2 effectors express Fas and FasL, but only Th2 effectors express high levels of FAP-1, a Fas-associated phosphatase that may act to inhibit Fas signaling. The rapid death of Th1 effectors leading to selective Th2 survival provides a novel mechanism for differential regulation of the two subsets.</dcterms:abstract>
    <dc:creator>Bradley, Linda</dc:creator>
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    <dc:contributor>Dutton, Richard W.</dc:contributor>
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