@article{Moran2017-10indiv-41288,
  year={2017},
  doi={10.1016/j.biopsycho.2017.09.014},
  title={The individual contribution of DSM 5 symptom clusters of PTSD, life events, and childhood adversity to frontal oscillatory brain asymmetry in a large sample of active combatants},
  volume={129},
  issn={0301-0511},
  journal={Biological psychology},
  pages={305--313},
  author={Moran, James and Crombach, Anselm and Elbert, Thomas and Nandi, Corina and Bambonyé, Manassé and Wienbruch, Christian and Lommen, Ursula and Weierstall, Roland}
}

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    <dc:contributor>Lommen, Ursula</dc:contributor>
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    <dcterms:title>The individual contribution of DSM 5 symptom clusters of PTSD, life events, and childhood adversity to frontal oscillatory brain asymmetry in a large sample of active combatants</dcterms:title>
    <dc:contributor>Wienbruch, Christian</dc:contributor>
    <dc:contributor>Moran, James</dc:contributor>
    <dc:contributor>Elbert, Thomas</dc:contributor>
    <dc:creator>Elbert, Thomas</dc:creator>
    <dc:creator>Crombach, Anselm</dc:creator>
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    <dc:contributor>Crombach, Anselm</dc:contributor>
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    <dc:contributor>Nandi, Corina</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-02-09T14:44:20Z</dc:date>
    <dc:language>eng</dc:language>
    <dc:creator>Weierstall, Roland</dc:creator>
    <dcterms:abstract xml:lang="eng">Post-Traumatic Stress Disorder (PTSD) has been linked to deviations in lateralized frontal functional oscillatory activity. This is possibly because left and right DLPFC have differential roles in regulating both memory and stress response, which are both dysfunctional in PTSD. However, previous results are heterogeneous, and could be attributable to individual symptom clusters, traumatic or aggressive life events, early life stress, or the interaction of these factors. In a large sample of active combatants (N=401), we regressed these factors on frontal electroencephalography (EEG) asymmetry across 5 frequency bands (delta: 2-4Hz; theta: 4-8Hz; alpha: 8-12Hz; beta: 12-24Hz; gamma: 24-48Hz). Negative cognition and mood was associated with stronger relative left delta and theta band power. Traumatic life events showed stronger right alpha and beta band power. Traumatic life events in interaction with hyperarousal predicted stronger relative right left-right imbalance (theta, alpha, and beta bands), whereas childhood adversity, in interaction with negative cognition and mood, predicted stronger relative left left-right imbalance (delta, theta, alpha and beta bands). The contribution of lateralized DLPFC dysfunction to PTSD is thus dependent on the individual complexities of subsymptom clusters and life history, and future studies need to take these factors into account.</dcterms:abstract>
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