Slow presynaptic mechanisms that mediate adaptation in the olfactory pathway of Drosophila

Martelli, Carlotta; Fiala, André

Slow presynaptic mechanisms that mediate adaptation in the olfactory pathway of Drosophila

Dateien

Martelli_2-1ojl7z0yuwsg17.pdfGröße: 4.15 MBDownloads: 274

Datum

2019

Autor:innen

Martelli, Carlotta

Fiala, André

Open Access-Veröffentlichung

Open Access Gold

Sammlungen

Biologie
Zukunftskolleg

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

eLife. 2019, 8, e43735. eISSN 2050-084X. Available under: doi: 10.7554/eLife.43735

Zusammenfassung

The olfactory system encodes odor stimuli as combinatorial activity of populations of neurons whose response depends on stimulus history. How and on which timescales previous stimuli affect these combinatorial representations remains unclear. We use in vivo optical imaging in Drosophila to analyze sensory adaptation at the first synaptic step along the olfactory pathway. We show that calcium signals in the axon terminals of olfactory receptor neurons (ORNs) do not follow the same adaptive properties as the firing activity measured at the antenna. While ORNs calcium responses are sustained on long timescales, calcium signals in the postsynaptic projection neurons (PNs) adapt within tens of seconds. We propose that this slow component of the postsynaptic response is mediated by a slow presynaptic depression of vesicle release and enables the combinatorial population activity of PNs to adjust to the mean and variance of fluctuating odor stimuli.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

MARTELLI, Carlotta, André FIALA, 2019. Slow presynaptic mechanisms that mediate adaptation in the olfactory pathway of Drosophila. In: eLife. 2019, 8, e43735. eISSN 2050-084X. Available under: doi: 10.7554/eLife.43735

BibTex

@article{Martelli2019-06-10presy-46462,
  year={2019},
  doi={10.7554/eLife.43735},
  title={Slow presynaptic mechanisms that mediate adaptation in the olfactory pathway of Drosophila},
  volume={8},
  journal={eLife},
  author={Martelli, Carlotta and Fiala, André},
  note={Article Number: e43735}
}

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