@article{Wang2022-01Genom-55661,
  year={2022},
  doi={10.1016/j.xinn.2021.100185},
  title={Genomic basis of evolutionary adaptation in a warm-blooded fish},
  number={1},
  volume={3},
  issn={2666-6758},
  journal={The Innovation},
  author={Wang, Xin and Qu, Meng and Liu, Yali and Schneider, Ralf F. and Song, Yue and Chen, Zelin and Zhang, Hao and Zhang, Yanhong and Meyer, Axel and Lin, Qiang},
  note={Article Number: 100185}
}

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/55661">
    <dc:creator>Liu, Yali</dc:creator>
    <dc:contributor>Zhang, Hao</dc:contributor>
    <dcterms:abstract xml:lang="eng">Few fishes have evolved elevated body temperatures compared to ambient temperatures and only in opah (Lampris spp) is the entire body affected. To understand the molecular basis of endothermy, we analyzed the opah genome and identified 23 genes with convergent amino acid substitutions across fish, birds, and mammals, including slc8b1, which encodes the mitochondrial Na+/Ca2+ exchanger and is essential for heart function and metabolic heat production. Among endothermic fishes, 44 convergent genes with suggestive metabolic functions were identified, such as glrx3, encoding a crucial protein for hemoglobin maturation. Numerous genes involved in the production and retention of metabolic heat were also found to be under positive selection. Analyses of opah’s unique inner heat-producing pectoral muscle layer, an evolutionary key-innovation, revealed that many proteins were co-opted from dorsal swimming muscles for thermogenesis and oxidative phosphorylation. Thus, the opah genome provides valuable resources and opportunities to uncover the genetic basis of thermal adaptations in fish.</dcterms:abstract>
    <dc:creator>Qu, Meng</dc:creator>
    <dcterms:title>Genomic basis of evolutionary adaptation in a warm-blooded fish</dcterms:title>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/55661"/>
    <dc:creator>Wang, Xin</dc:creator>
    <dc:contributor>Song, Yue</dc:contributor>
    <dc:creator>Meyer, Axel</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-11-25T14:11:52Z</dc:date>
    <dc:creator>Zhang, Hao</dc:creator>
    <dcterms:issued>2022-01</dcterms:issued>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/55661/1/Wang_2-1ptpu3vrw0vf23.pdf"/>
    <dc:contributor>Meyer, Axel</dc:contributor>
    <dc:creator>Schneider, Ralf F.</dc:creator>
    <dc:contributor>Qu, Meng</dc:contributor>
    <dc:contributor>Zhang, Yanhong</dc:contributor>
    <dc:creator>Chen, Zelin</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Lin, Qiang</dc:creator>
    <dc:contributor>Schneider, Ralf F.</dc:contributor>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/4.0/"/>
    <dc:creator>Zhang, Yanhong</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Song, Yue</dc:creator>
    <dc:contributor>Chen, Zelin</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-11-25T14:11:52Z</dcterms:available>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 International</dc:rights>
    <dc:contributor>Liu, Yali</dc:contributor>
    <dc:contributor>Lin, Qiang</dc:contributor>
    <dc:contributor>Wang, Xin</dc:contributor>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/55661/1/Wang_2-1ptpu3vrw0vf23.pdf"/>
    <dc:language>eng</dc:language>
  </rdf:Description>
</rdf:RDF>