@article{AlmuedoCastillo2018Scale-56055,
  year={2018},
  doi={10.1038/s41556-018-0155-7},
  title={Scale-invariant patterning by size-dependent inhibition of Nodal signalling},
  number={9},
  volume={20},
  issn={1465-7392},
  journal={Nature Cell Biology},
  pages={1032--1042},
  author={Almuedo-Castillo, María and Bläßle, Alexander and Mörsdorf, David and Marcon, Luciano and Soh, Gary H. and Rogers, Katherine W. and Schier, Alexander F. and Müller, Patrick}
}

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    <dc:contributor>Bläßle, Alexander</dc:contributor>
    <dc:creator>Müller, Patrick</dc:creator>
    <dc:contributor>Müller, Patrick</dc:contributor>
    <dc:creator>Soh, Gary H.</dc:creator>
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    <dc:creator>Marcon, Luciano</dc:creator>
    <dc:contributor>Marcon, Luciano</dc:contributor>
    <dc:contributor>Almuedo-Castillo, María</dc:contributor>
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    <dc:language>eng</dc:language>
    <dc:creator>Rogers, Katherine W.</dc:creator>
    <dc:creator>Bläßle, Alexander</dc:creator>
    <dc:contributor>Mörsdorf, David</dc:contributor>
    <dc:creator>Schier, Alexander F.</dc:creator>
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    <dcterms:title>Scale-invariant patterning by size-dependent inhibition of Nodal signalling</dcterms:title>
    <dc:contributor>Schier, Alexander F.</dc:contributor>
    <dc:contributor>Soh, Gary H.</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-01-04T09:49:21Z</dc:date>
    <dc:creator>Almuedo-Castillo, María</dc:creator>
    <dc:contributor>Rogers, Katherine W.</dc:contributor>
    <dc:creator>Mörsdorf, David</dc:creator>
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    <dcterms:abstract xml:lang="eng">Individuals can vary substantially in size, but the proportions of their body plans are often maintained. We generated smaller zebrafish by removing 30% of their cells at the blastula stages and found that these embryos developed into normally patterned individuals. Strikingly, the proportions of all germ layers adjusted to the new embryo size within 2 hours after cell removal. As Nodal-Lefty signalling controls germ-layer patterning, we performed a computational screen for scale-invariant models of this activator-inhibitor system. This analysis predicted that the concentration of the highly diffusive inhibitor Lefty increases in smaller embryos, leading to a decreased Nodal activity range and contracted germ-layer dimensions. In vivo studies confirmed that Lefty concentration increased in smaller embryos, and embryos with reduced Lefty levels or with diffusion-hindered Lefty failed to scale their tissue proportions. These results reveal that size-dependent inhibition of Nodal signalling allows scale-invariant patterning.</dcterms:abstract>
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