@article{Plummer2019-02-05Human-45642,
  year={2019},
  doi={10.1038/s41598-018-38130-0},
  title={A Human iPSC-derived 3D platform using primary brain cancer cells to study drug development and personalized medicine},
  number={1},
  volume={9},
  journal={Scientific Reports},
  author={Plummer, Simon and Wallace, Stephanie and Ball, Graeme and Lloyd, Roslyn and Schiapparelli, Paula and Quiñones-Hinojosa, Alfredo and Hartung, Thomas and Pamies, David},
  note={Article Number: 1407}
}

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    <dc:language>eng</dc:language>
    <dc:creator>Schiapparelli, Paula</dc:creator>
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    <dc:creator>Pamies, David</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-04-15T14:10:00Z</dc:date>
    <dc:creator>Ball, Graeme</dc:creator>
    <dc:contributor>Schiapparelli, Paula</dc:contributor>
    <dc:contributor>Lloyd, Roslyn</dc:contributor>
    <dc:contributor>Plummer, Simon</dc:contributor>
    <dc:contributor>Hartung, Thomas</dc:contributor>
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    <dc:creator>Wallace, Stephanie</dc:creator>
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    <dc:contributor>Pamies, David</dc:contributor>
    <dc:creator>Quiñones-Hinojosa, Alfredo</dc:creator>
    <dcterms:title>A Human iPSC-derived 3D platform using primary brain cancer cells to study drug development and personalized medicine</dcterms:title>
    <dc:creator>Lloyd, Roslyn</dc:creator>
    <dc:contributor>Quiñones-Hinojosa, Alfredo</dc:contributor>
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    <dc:contributor>Wallace, Stephanie</dc:contributor>
    <dcterms:abstract xml:lang="eng">A high throughput histology (microTMA) platform was applied for testing drugs against tumors in a novel 3D heterotypic glioblastoma brain sphere (gBS) model consisting of glioblastoma tumor cells, iPSC-derived neurons, glial cells and astrocytes grown in a spheroid. The differential responses of gBS tumors and normal neuronal cells to sustained treatments with anti-cancer drugs temozolomide (TMZ) and doxorubicin (DOX) were investigated. gBS were exposed to TMZ or DOX over a 7-day period. Untreated gBS tumors increased in size over a 4-week culture period, however, there was no increase in the number of normal neuronal cells. TMZ (100 uM) and DOX (0.3 uM) treatments caused ~30% (P~0.07) and ~80% (P &lt; 0.001) decreases in the size of the tumors, respectively. Neither treatment altered the number of normal neuronal cells in the model. The anti-tumor effects of TMZ and DOX were mediated in part by selective induction of apoptosis. This platform provides a novel approach for screening new anti-glioblastoma agents and evaluating different treatment options for a given patient.</dcterms:abstract>
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    <dc:creator>Hartung, Thomas</dc:creator>
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    <dc:contributor>Ball, Graeme</dc:contributor>
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    <dcterms:issued>2019-02-05</dcterms:issued>
    <dc:rights>Attribution 4.0 International</dc:rights>
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