Prefrontally Driven Downregulation of Neural Synchrony Mediates Goal-Directed Forgetting

Hanslmayr, Simon; Volberg, Gregor; Wimber, Maria; Oehler, Nora; Staudigl, Tobias; Hartmann, Thomas; Raabe, Markus; Greenlee, Mark; Bäuml, Karl-Heinz

Prefrontally Driven Downregulation of Neural Synchrony Mediates Goal-Directed Forgetting

Dateien

Hanslmayretal_207399.pdfGröße: 7.43 MBDownloads: 954

Datum

2012

Autor:innen

Hanslmayr, Simon

Volberg, Gregor

Wimber, Maria

Oehler, Nora

Staudigl, Tobias

Hartmann, Thomas

Raabe, Markus

Greenlee, Mark

Bäuml, Karl-Heinz

Projekt

Wie das synchronisierte Gehirn Langzeitgedächtnisinhalte formt

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Psychologie
Zukunftskolleg

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Journal of Neuroscience. 2012, 32(42), pp. 14742-14751. ISSN 0270-6474. eISSN 1529-2401. Available under: doi: 10.1523/JNEUROSCI.1777-12.2012

Zusammenfassung

Neural synchronization between distant cell assemblies is crucial for the formation of new memories. To date, however, it remains unclear whether higher-order brain regions can adaptively regulate neural synchrony to control memory processing in humans. We explored this question in two experiments using a voluntary forgetting task. In the first experiment, we simultaneously recorded electroencephalography along with fMRI. The results show that a reduction in neural synchrony goes hand-in-hand with a BOLD signal increase in the left dorsolateral prefrontal cortex (dlPFC) when participants are cued to forget previously studied information. In the
second experiment, we directly stimulated the left dlPFC with repetitive transcranial magnetic stimulation during the same task, and show that such stimulation specifically boosts the behavioral forgetting effect and induces a reduction in neural synchrony. These results suggest that prefrontally driven downregulation of long-range neural synchronization mediates goal-directed forgetting of long-term memories.

Fachgebiet (DDC)

150 Psychologie

Schlagwörter

Fogetting, Episodic Memory, fMRI, EEG, rTMS, dlPFC, Oscillations

Zitieren

ISO 690

HANSLMAYR, Simon, Gregor VOLBERG, Maria WIMBER, Nora OEHLER, Tobias STAUDIGL, Thomas HARTMANN, Markus RAABE, Mark GREENLEE, Karl-Heinz BÄUML, 2012. Prefrontally Driven Downregulation of Neural Synchrony Mediates Goal-Directed Forgetting. In: Journal of Neuroscience. 2012, 32(42), pp. 14742-14751. ISSN 0270-6474. eISSN 1529-2401. Available under: doi: 10.1523/JNEUROSCI.1777-12.2012

BibTex

@article{Hanslmayr2012-10-17Prefr-20739,
  year={2012},
  doi={10.1523/JNEUROSCI.1777-12.2012},
  title={Prefrontally Driven Downregulation of Neural Synchrony Mediates Goal-Directed Forgetting},
  number={42},
  volume={32},
  issn={0270-6474},
  journal={Journal of Neuroscience},
  pages={14742--14751},
  author={Hanslmayr, Simon and Volberg, Gregor and Wimber, Maria and Oehler, Nora and Staudigl, Tobias and Hartmann, Thomas and Raabe, Markus and Greenlee, Mark and Bäuml, Karl-Heinz}
}

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