The role of octopamine and tyramine in Drosophila larval locomotion

Selcho, Mareike; Pauls, Dennis; Jundi, Basil el; Stocker, Reinhard F.; Thum, Andreas

The role of octopamine and tyramine in Drosophila larval locomotion

Dateien

Selcho_217701.pdfGröße: 11.45 MBDownloads: 2049

Datum

2012

URI (zitierfähiger Link)

http://nbn-resolving.de/urn:nbn:de:bsz:352-217701

DOI (zitierfähiger Link)

https://doi.org/10.1002/cne.23152

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

The Journal of Comparative Neurology. 2012, 520(16), pp. 3764-3785. ISSN 0021-9967. eISSN 1096-9861. Available under: doi: 10.1002/cne.23152

Zusammenfassung

The characteristic crawling behavior of Drosophila larvae consists of a series of rhythmic waves of peristalsis and episodes of head swinging and turning. The two biogenic amines octopamine and tyramine have recently been shown to modulate various parameters of locomotion, such as muscle contraction, the time spent in pausing or forward locomotion, and the initiation and maintenance of rhythmic motor patterns. By using mutants having altered octopamine and tyramine levels and by genetic interference with both systems we confirm that signaling of these two amines is necessary for larval locomotion. We show that a small set of about 40 octopaminergic/tyraminergic neurons within the ventral nerve cord is sufficient to trigger proper larval locomotion. Using single-cell clones, we describe the morphology of these neurons individually. Given various potential roles of octopamine and tyramine in the larval brain, such as locomotion, learning and memory, stress-induced behaviors or the regulation of the energy state, functions that are often not easy to discriminate, we dissect here for the first time a subset of this complex circuit that modulates specifically larval locomotion. Thus, these data will help to understand—for a given neuronal modulator—how specific behavioral functions are executed within distinct subcircuits of a complex neuronal network

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

SELCHO, Mareike, Dennis PAULS, Basil el JUNDI, Reinhard F. STOCKER, Andreas THUM, 2012. The role of octopamine and tyramine in Drosophila larval locomotion. In: The Journal of Comparative Neurology. 2012, 520(16), pp. 3764-3785. ISSN 0021-9967. eISSN 1096-9861. Available under: doi: 10.1002/cne.23152

BibTex

@article{Selcho2012-11-01octop-21770,
  year={2012},
  doi={10.1002/cne.23152},
  title={The role of octopamine and tyramine in Drosophila larval locomotion},
  number={16},
  volume={520},
  issn={0021-9967},
  journal={The Journal of Comparative Neurology},
  pages={3764--3785},
  author={Selcho, Mareike and Pauls, Dennis and Jundi, Basil el and Stocker, Reinhard F. and Thum, Andreas}
}

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Universitätsbibliographie

Ja