@article{Yoon2013Scaff-26044,
  year={2013},
  doi={10.1038/ncomms3939},
  title={Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination},
  volume={4},
  journal={Nature Communications},
  author={Yoon, Je-Hyun and Abdelmohsen, Kotb and Kim, Jiyoung and Yang, Xiaoling and Martindale, Jennifer L. and Tominaga-Yamanaka, Kumiko and White, Elizabeth J. and Orjalo, Arturo V. and Rinn, John L. and Kreft, Stefan G. and Wilson, Gerald M. and Gorospe, Myriam},
  note={Article Number: 2939}
}

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    <dc:contributor>Martindale, Jennifer L.</dc:contributor>
    <dc:contributor>Orjalo, Arturo V.</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-01-24T07:38:54Z</dc:date>
    <dc:contributor>Yang, Xiaoling</dc:contributor>
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    <dc:creator>Rinn, John L.</dc:creator>
    <dcterms:abstract xml:lang="eng">Although mammalian long non-coding (lnc)RNAs are best known for modulating transcription, their post-transcriptional influence on mRNA splicing, stability and translation is emerging. Here we report a post-translational function for the lncRNA HOTAIR as an inducer of ubiquitin-mediated proteolysis. HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, Dzip3 and Mex3b, as well as with their respective ubiquitination substrates, Ataxin-1 and Snurportin-1. In this manner, HOTAIR facilitates the ubiquitination of Ataxin-1 by Dzip3 and Snurportin-1 by Mex3b in cells and in vitro, and accelerates their degradation. HOTAIR levels are highly upregulated in senescent cells, causing rapid decay of targets Ataxin-1 and Snurportin-1, and preventing premature senescence. These results uncover a role for a lncRNA, HOTAIR, as a platform for protein ubiquitination.</dcterms:abstract>
    <dcterms:bibliographicCitation>Nature Communications ; 4 (2013). - 2939</dcterms:bibliographicCitation>
    <dc:creator>Kreft, Stefan G.</dc:creator>
    <dc:creator>White, Elizabeth J.</dc:creator>
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    <dc:contributor>Abdelmohsen, Kotb</dc:contributor>
    <dc:creator>Tominaga-Yamanaka, Kumiko</dc:creator>
    <dc:contributor>Yoon, Je-Hyun</dc:contributor>
    <dc:contributor>White, Elizabeth J.</dc:contributor>
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