C-(alpha-D-Glucopyranosyl)-phenyldiazomethanes - Irreversible Inhibitors of alpha-Glucosidase

Geng, Yiqun; Kumar, Amit; Faidallah, Hassan M.; Albar, Hassan A.; Mhkalid, Ibrahim A.; Schmidt, Richard R.

C-(alpha-D-Glucopyranosyl)-phenyldiazomethanes - Irreversible Inhibitors of alpha-Glucosidase

Dateien

Geng_260610.pdfGröße: 2.32 MBDownloads: 334

Datum

2013

Autor:innen

Geng, Yiqun

Kumar, Amit

Faidallah, Hassan M.

Albar, Hassan A.

Mhkalid, Ibrahim A.

Schmidt, Richard R.

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Chemie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Bioorganic & Medicinal Chemistry. 2013, 21(16), pp. 4793-4802. ISSN 0968-0896. eISSN 1464-3391. Available under: doi: 10.1016/j.bmc.2013.05.055

Zusammenfassung

Several C-(alpha-D-glucopyranosyl)-phenyldiazomethanes, with different substituent groups at the paraposition of the phenyl ring, were prepared. The stabilities of these diazo compounds were investigated through NMR and UV monitoring. The para-cyano substituted diazo compound was found to be stable in neutral media (pH 7.0 buffer) and could be isolated. Inhibitory activity investigations indicated that this compound is an irreversible inhibitor against a-glucosidase from Saccharomyces cerevisiae.

Fachgebiet (DDC)

540 Chemie

Schlagwörter

a-Glucosidase, Irreversible inhibition, Diazo compounds, carbohydrate, synthesis

Zitieren

ISO 690

GENG, Yiqun, Amit KUMAR, Hassan M. FAIDALLAH, Hassan A. ALBAR, Ibrahim A. MHKALID, Richard R. SCHMIDT, 2013. C-(alpha-D-Glucopyranosyl)-phenyldiazomethanes - Irreversible Inhibitors of alpha-Glucosidase. In: Bioorganic & Medicinal Chemistry. 2013, 21(16), pp. 4793-4802. ISSN 0968-0896. eISSN 1464-3391. Available under: doi: 10.1016/j.bmc.2013.05.055

BibTex

@article{Geng2013-08-15Calph-26061,
  year={2013},
  doi={10.1016/j.bmc.2013.05.055},
  title={C-(alpha-D-Glucopyranosyl)-phenyldiazomethanes - Irreversible Inhibitors of alpha-Glucosidase},
  number={16},
  volume={21},
  issn={0968-0896},
  journal={Bioorganic & Medicinal Chemistry},
  pages={4793--4802},
  author={Geng, Yiqun and Kumar, Amit and Faidallah, Hassan M. and Albar, Hassan A. and Mhkalid, Ibrahim A. and Schmidt, Richard R.}
}

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