Estimation of delay times in biological systems

Müller, Thomas; Lauk, Michael; Reinhard, Matthias; Hetzel, Andreas; Lücking, Carl H.; Timmer, Jens

Estimation of delay times in biological systems

Dateien

Mueller_272488.pdfGröße: 199.22 KBDownloads: 456

Datum

2003

Autor:innen

Müller, Thomas

Lauk, Michael

Reinhard, Matthias

Hetzel, Andreas

Lücking, Carl H.

Timmer, Jens

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Philosophie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Annals of Biomedical Engineering. 2003, 31(11), pp. 1423-1439. ISSN 0090-6964. eISSN 1573-9686. Available under: doi: 10.1114/1.1617984

Zusammenfassung

The problem of delay time estimation in biological systems is addressed with the focus on practical applicability of methods. Four delay time estimators are described: a cross correlation method and three increasingly sophisticated interpretations of the phase spectrum, ranging from a pointwise interpretation of the phase spectrum in terms of a delay to a Hilbert transform method. The four methods are compared through simulation studies showing that, in general, the Hilbert transform method performs best. The methods are then used to estimate delay times in three physiological systems: vestibular stimulation, cerebral autoregulation, and human orthostatic tremor. In all three cases, the Hilbert transform method yields the best results, leading in some cases to physiologically more sensible interpretations of experiments than the other methods.

Fachgebiet (DDC)

100 Philosophie

Schlagwörter

Homeostasis, Models, Biological, Reaction Time, Time Factors, Tremor

Zitieren

ISO 690

MÜLLER, Thomas, Michael LAUK, Matthias REINHARD, Andreas HETZEL, Carl H. LÜCKING, Jens TIMMER, 2003. Estimation of delay times in biological systems. In: Annals of Biomedical Engineering. 2003, 31(11), pp. 1423-1439. ISSN 0090-6964. eISSN 1573-9686. Available under: doi: 10.1114/1.1617984

BibTex

@article{Muller2003Estim-27248,
  year={2003},
  doi={10.1114/1.1617984},
  title={Estimation of delay times in biological systems},
  number={11},
  volume={31},
  issn={0090-6964},
  journal={Annals of Biomedical Engineering},
  pages={1423--1439},
  author={Müller, Thomas and Lauk, Michael and Reinhard, Matthias and Hetzel, Andreas and Lücking, Carl H. and Timmer, Jens}
}

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