The influence of methylphenidate on the power spectrum of ADHD children : an MEG study
Dateien
Datum
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Publikationsstatus
Erschienen in
Zusammenfassung
Background
The present study was dedicated to investigate the influence of Methylphenidate (MPH) on cortical processing of children who were diagnosed with different subtypes of Attention Deficit Hyperactivity Disorder (ADHD). As all of the previous studies investigating power differences in different frequency bands have been using EEG, mostly with a relatively small number of electrodes our aim was to obtain new aspects using high density magnetoencephalography (MEG).
Methods
35 children (6 female, 29 male) participated in this study. Mean age was 11.7 years (± 1.92 years). 17 children were diagnosed of having an Attention-Deficit/Hyperactivity Disorder of the combined type (ADHDcom, DSM IV code 314.01); the other 18 were diagnosed for ADHD of the predominantly inattentive type (ADHDin, DSM IV code 314.0). We measured the MEG during a 5 minute resting period with a 148-channel magnetometer system (MAGNES™ 2500 WH, 4D Neuroimaging, San Diego, USA). Power values were averaged for 5 bands: Delta (D, 1.5–3.5 Hz), Theta (T, 3.5–7.5 Hz), Alpha (A, 7.5–12.5 Hz), Beta (B, 12.5–25 Hz) and Global (GL, 1.5–25 Hz).). Additionally, attention was measured behaviourally using the D2 test of attention with and without medication.
Results
The global power of the frequency band from 1.5 to 25 Hz increased with MPH. Relative Theta was found to be higher in the left hemisphere after administration of MPH than before. A positive correlation was found between D2 test improvement and MPH-induced power changes in the Theta band over the left frontal region. A linear regression was computed and confirmed that the larger the improvement in D2 test performance, the larger the increase in Theta after MPH application.
Conclusion
Main effects induced by medication were found in frontal regions. Theta band activity increased over the left hemisphere after MPH application. This finding contradicts EEG results of several groups who found lower levels of Theta power after MPH application. As relative Theta correlates with D2 test improvement we conclude that MEG provide complementary and therefore important new insights to ADHD.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
Schlagwörter
Konferenz
Rezension
Zitieren
ISO 690
WIENBRUCH, Christian, Isabella PAUL, Susanne BAUER, Hermann KIVELITZ, 2005. The influence of methylphenidate on the power spectrum of ADHD children : an MEG study. In: BMC Psychiatry. 2005, 5(1), 29. ISSN 1471-244X. eISSN 1471-244X. Available under: doi: 10.1186/1471-244X-5-29BibTex
@article{Wienbruch2005influ-28163,
year={2005},
doi={10.1186/1471-244X-5-29},
title={The influence of methylphenidate on the power spectrum of ADHD children : an MEG study},
number={1},
volume={5},
issn={1471-244X},
journal={BMC Psychiatry},
author={Wienbruch, Christian and Paul, Isabella and Bauer, Susanne and Kivelitz, Hermann},
note={Article Number: 29}
}RDF
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bibo="http://purl.org/ontology/bibo/"
xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:void="http://rdfs.org/ns/void#"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#" >
<rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28163">
<dc:creator>Kivelitz, Hermann</dc:creator>
<dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
<dc:contributor>Kivelitz, Hermann</dc:contributor>
<dc:creator>Paul, Isabella</dc:creator>
<dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
<bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/28163"/>
<dc:creator>Bauer, Susanne</dc:creator>
<void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
<dc:rights>terms-of-use</dc:rights>
<dc:language>eng</dc:language>
<dcterms:bibliographicCitation>BMC Psychiatry ; 5 (2005). - 29</dcterms:bibliographicCitation>
<dc:contributor>Bauer, Susanne</dc:contributor>
<foaf:homepage rdf:resource="http://localhost:8080/"/>
<dc:contributor>Paul, Isabella</dc:contributor>
<dcterms:issued>2005</dcterms:issued>
<dcterms:title>The influence of methylphenidate on the power spectrum of ADHD children : an MEG study</dcterms:title>
<dcterms:abstract xml:lang="eng">Background<br /><br /><br />The present study was dedicated to investigate the influence of Methylphenidate (MPH) on cortical processing of children who were diagnosed with different subtypes of Attention Deficit Hyperactivity Disorder (ADHD). As all of the previous studies investigating power differences in different frequency bands have been using EEG, mostly with a relatively small number of electrodes our aim was to obtain new aspects using high density magnetoencephalography (MEG).<br /><br /><br /><br />Methods<br /><br /><br />35 children (6 female, 29 male) participated in this study. Mean age was 11.7 years (± 1.92 years). 17 children were diagnosed of having an Attention-Deficit/Hyperactivity Disorder of the combined type (ADHDcom, DSM IV code 314.01); the other 18 were diagnosed for ADHD of the predominantly inattentive type (ADHDin, DSM IV code 314.0). We measured the MEG during a 5 minute resting period with a 148-channel magnetometer system (MAGNES™ 2500 WH, 4D Neuroimaging, San Diego, USA). Power values were averaged for 5 bands: Delta (D, 1.5–3.5 Hz), Theta (T, 3.5–7.5 Hz), Alpha (A, 7.5–12.5 Hz), Beta (B, 12.5–25 Hz) and Global (GL, 1.5–25 Hz).). Additionally, attention was measured behaviourally using the D2 test of attention with and without medication.<br /><br /><br /><br />Results<br /><br /><br />The global power of the frequency band from 1.5 to 25 Hz increased with MPH. Relative Theta was found to be higher in the left hemisphere after administration of MPH than before. A positive correlation was found between D2 test improvement and MPH-induced power changes in the Theta band over the left frontal region. A linear regression was computed and confirmed that the larger the improvement in D2 test performance, the larger the increase in Theta after MPH application.<br /><br /><br /><br />Conclusion<br /><br /><br />Main effects induced by medication were found in frontal regions. Theta band activity increased over the left hemisphere after MPH application. This finding contradicts EEG results of several groups who found lower levels of Theta power after MPH application. As relative Theta correlates with D2 test improvement we conclude that MEG provide complementary and therefore important new insights to ADHD.</dcterms:abstract>
<dc:creator>Wienbruch, Christian</dc:creator>
<dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-06-26T09:40:08Z</dc:date>
<dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/28163/1/Wienbruch_281633.pdf"/>
<dc:contributor>Wienbruch, Christian</dc:contributor>
<dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
<dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-06-26T09:40:08Z</dcterms:available>
<dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/28163/1/Wienbruch_281633.pdf"/>
</rdf:Description>
</rdf:RDF>
