Mammalian HECT ubiquitin-protein ligases : biological and pathophysiological aspects

Scheffner, Martin; Kumar, Sharad

Mammalian HECT ubiquitin-protein ligases : biological and pathophysiological aspects

Dateien

Scheffner_285241.pdfGröße: 200.87 KBDownloads: 352

Datum

2014

Autor:innen

Scheffner, Martin

Kumar, Sharad

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2014, 1843(1), pp. 61-74. ISSN 0167-4889. Available under: doi: 10.1016/j.bbamcr.2013.03.024

Zusammenfassung

Members of the HECT family of E3 ubiquitin-protein ligases are characterized by a C-terminal HECT domain that catalyzes the covalent attachment of ubiquitin to substrate proteins and by N-terminal extensions of variable length and domain architecture that determine the substrate spectrum of a respective HECT E3. Since their discovery in 1995, it has become clear that deregulation of distinct HECT E3s plays an eminent role in human disease or disease-related processes including cancer, cardiovascular and neurological disorders, viral infections, and immune response. Thus, a detailed understanding of the structure–function aspects of HECT E3s as well as the identification and characterization of the substrates and regulators of HECT E3s is critical in developing new approaches in the treatment of respective diseases. In this review, we summarize what is currently known about mammalian HECT E3s, with a focus on their biological functions and roles in pathophysiology.This article is part of a Special Issue entitled: Ubiquitin–Proteasome System. Guest Editors: Thomas Sommer and Dieter H. Wolf.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

HECT domain, ubiquitin ligase, ubiquitination, disease, signaling

Zitieren

ISO 690

SCHEFFNER, Martin, Sharad KUMAR, 2014. Mammalian HECT ubiquitin-protein ligases : biological and pathophysiological aspects. In: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2014, 1843(1), pp. 61-74. ISSN 0167-4889. Available under: doi: 10.1016/j.bbamcr.2013.03.024

BibTex

@article{Scheffner2014-01Mamma-28524,
  year={2014},
  doi={10.1016/j.bbamcr.2013.03.024},
  title={Mammalian HECT ubiquitin-protein ligases : biological and pathophysiological aspects},
  number={1},
  volume={1843},
  issn={0167-4889},
  journal={Biochimica et Biophysica Acta (BBA) - Molecular Cell Research},
  pages={61--74},
  author={Scheffner, Martin and Kumar, Sharad}
}

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