@article{Morath2014-07effec-28951,
  year={2014},
  doi={10.1016/j.jpsychires.2014.03.016},
  title={The effect of trauma-focused therapy on the altered T cell distribution in individuals with PTSD : evidence from a randomized controlled trial},
  volume={54},
  issn={0022-3956},
  journal={Journal of Psychiatric Research},
  pages={1--10},
  author={Morath, Julia and Gola, Hannah and Sommershof, Annette and Hamuni, Gilava and Kolassa, Stephan and Catani, Claudia and Adenauer, Hannah and Ruf-Leuschner, Martina and Schauer, Maggie and Elbert, Thomas and Gröttrup, Marcus and Kolassa, Iris-Tatjana}
}

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    <dc:contributor>Schauer, Maggie</dc:contributor>
    <dc:contributor>Hamuni, Gilava</dc:contributor>
    <dcterms:title>The effect of trauma-focused therapy on the altered T cell distribution in individuals with PTSD : evidence from a randomized controlled trial</dcterms:title>
    <dc:contributor>Sommershof, Annette</dc:contributor>
    <dcterms:issued>2014-07</dcterms:issued>
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    <dc:creator>Elbert, Thomas</dc:creator>
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    <dc:creator>Kolassa, Stephan</dc:creator>
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    <dc:contributor>Adenauer, Hannah</dc:contributor>
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    <dcterms:abstract xml:lang="eng">Posttraumatic stress disorder (PTSD) is associated with a reduced ratio of naïve cytotoxic T lymphocytes, an increased ratio of memory cytotoxic T lymphocytes, and a reduced proportion of FoxP3+ regulatory T lymphocytes. This study investigated whether these immunological alterations are reversible through an evidence-based psychotherapeutic treatment. Therefore, 34 individuals with PTSD were randomly assigned to either a treatment condition of 12 sessions narrative exposure therapy (NET) or a waitlist control (WLC) group. PTSD symptoms were significantly reduced in the NET group, but not in the WLC group, four months post-therapy (effect size: Hedges' g = −1.61). One year after therapy, PTSD symptoms were improved even further in the NET group compared to baseline (Hedges' g = −1.96). This symptom improvement was mirrored in an increase in the originally reduced proportion of regulatory T cells (T&lt;sub&gt;regs&lt;/sub&gt;) in the NET group at the one-year follow-up, when comparing subgroups matched for baseline T&lt;sub&gt;reg&lt;/sub&gt; numbers. However, no changes were found for the initially reduced proportion of CD45RA+CCR7+ naïve T lymphocytes. In conclusion, NET was effective in reducing trauma-related PTSD symptoms and had a positive effect on the proportion of T&lt;sub&gt;regs&lt;/sub&gt; cells, thus demonstrating an effect of psychotherapy on an immunological level. Yet, the shift in the proportion of naïve and memory T lymphocytes in individuals with PTSD, discussed in the literature as a correlate of premature immunosenescence, was not reversible and thus might render these patients permanently more susceptible to infectious diseases.</dcterms:abstract>
    <dc:contributor>Catani, Claudia</dc:contributor>
    <dc:creator>Kolassa, Iris-Tatjana</dc:creator>
    <dc:creator>Hamuni, Gilava</dc:creator>
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    <dc:creator>Gola, Hannah</dc:creator>
    <dc:creator>Catani, Claudia</dc:creator>
    <dc:contributor>Gola, Hannah</dc:contributor>
    <dc:creator>Morath, Julia</dc:creator>
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    <dc:contributor>Kolassa, Stephan</dc:contributor>
    <dc:contributor>Ruf-Leuschner, Martina</dc:contributor>
    <dc:contributor>Morath, Julia</dc:contributor>
    <dc:contributor>Elbert, Thomas</dc:contributor>
    <dcterms:bibliographicCitation>Journal of psychiatric research ; 54 (2014). - S. 1-10</dcterms:bibliographicCitation>
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