Molecular basis for detection of invading pathogens in the brain

Falsig, Jeppe; Beek, Johan van; Hermann, Corinna; Leist, Marcel

Molecular basis for detection of invading pathogens in the brain

Dateien

Falsig edit.pdfGröße: 8.79 MBDownloads: 873

Datum

2008

Autor:innen

Falsig, Jeppe

Beek, Johan van

Hermann, Corinna

Leist, Marcel

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie
Zukunftskolleg

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Journal of Neuroscience Research. 2008, 86(7), pp. 1434-1447. ISSN 0360-4012. eISSN 1097-4547. Available under: doi: 10.1002/jnr.21590

Zusammenfassung

Classical immunology textbooks have described the central nervous system as an immune-privileged site, i.e., as devoid of inflammatory and host-vs.-graft immunoreactions. This view has been refined, since we now know that hematopoietic cells infiltrate the CNS under certain circumstances and that CNS-resident cells are capable of launching an innate immune response. Microglia cells express an extensive repertoire of pattern-recognition receptors and act as sentinels surveilling the CNS for possible damage or infection. Astrocytes are the most abundant cell type in the brain, and they are capable of launching a strong supportive innate immune response. Novel findings show that both astrocytes and, surprisingly, even neurons express pattern-recognition receptors. Activation of these receptors leads to a functional response, indicating that cells other than microglia are capable of initiating a primary innate immune response against CNS-invading pathogens. Here, we put these findings into context with what has been learned from recent in vitro and in vivo experiments about the initiation of an innate immune response in the brain.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

pathogen-associated molecular patterns, pattern recognition receptors, microglia, CNS, astrocytes

Zitieren

ISO 690

FALSIG, Jeppe, Johan van BEEK, Corinna HERMANN, Marcel LEIST, 2008. Molecular basis for detection of invading pathogens in the brain. In: Journal of Neuroscience Research. 2008, 86(7), pp. 1434-1447. ISSN 0360-4012. eISSN 1097-4547. Available under: doi: 10.1002/jnr.21590

BibTex

@article{Falsig2008-05-15Molec-1174,
  year={2008},
  doi={10.1002/jnr.21590},
  title={Molecular basis for detection of invading pathogens in the brain},
  number={7},
  volume={86},
  issn={0360-4012},
  journal={Journal of Neuroscience Research},
  pages={1434--1447},
  author={Falsig, Jeppe and Beek, Johan van and Hermann, Corinna and Leist, Marcel}
}

RDF

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/1174">
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:37Z</dc:date>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/>
    <dc:creator>Hermann, Corinna</dc:creator>
    <dc:contributor>Leist, Marcel</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:language>eng</dc:language>
    <dc:contributor>Beek, Johan van</dc:contributor>
    <dc:creator>Beek, Johan van</dc:creator>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/1174/1/Falsig%20edit.pdf"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Hermann, Corinna</dc:contributor>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:rights>terms-of-use</dc:rights>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/1174"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:37Z</dcterms:available>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/1174/1/Falsig%20edit.pdf"/>
    <dcterms:title>Molecular basis for detection of invading pathogens in the brain</dcterms:title>
    <dc:contributor>Falsig, Jeppe</dc:contributor>
    <dc:creator>Falsig, Jeppe</dc:creator>
    <dc:creator>Leist, Marcel</dc:creator>
    <dcterms:abstract xml:lang="eng">Classical immunology textbooks have described the central nervous system as an immune-privileged site, i.e., as devoid of inflammatory and host-vs.-graft immunoreactions. This view has been refined, since we now know that hematopoietic cells infiltrate the CNS under certain circumstances and that CNS-resident cells are capable of launching an innate immune response. Microglia cells express an extensive repertoire of pattern-recognition receptors and act as sentinels surveilling the CNS for possible damage or infection. Astrocytes are the most abundant cell type in the brain, and they are capable of launching a strong supportive innate immune response. Novel findings show that both astrocytes and, surprisingly, even neurons express pattern-recognition receptors. Activation of these receptors leads to a functional response, indicating that cells other than microglia are capable of initiating a primary innate immune response against CNS-invading pathogens. Here, we put these findings into context with what has been learned from recent in vitro and in vivo experiments about the initiation of an innate immune response in the brain.</dcterms:abstract>
    <dcterms:bibliographicCitation>First publ. in: Journal of Neuroscience Research ; 86 (2008), 7. - pp. 1434-1447</dcterms:bibliographicCitation>
    <dcterms:issued>2008-05-15</dcterms:issued>
  </rdf:Description>
</rdf:RDF>

Universitätsbibliographie

Ja