Varied DNA Polymerase : Substrate Interactions in the Nucleotide Binding Pocket

Strerath, Michael; Summerer, Daniel; Marx, Andreas

Varied DNA Polymerase : Substrate Interactions in the Nucleotide Binding Pocket

Dateien

12819.pdfGröße: 259.87 KBDownloads: 397

Datum

2002

Autor:innen

Strerath, Michael

Summerer, Daniel

Marx, Andreas

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Chemie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

ChemBioChem. 2002, 3(6), pp. 578-580. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/1439-7633(20020603)3:6<578::AID-CBIC578>3.0.CO;2-W

Zusammenfassung

Replication fidelity: How do DNA polymerases ensure selectivity? Further insights into interactions between a DNA polymerase and the sugar moiety of the template nucleotide were gained through functional enzyme studies, which employed site-specifically modified DNA substrates (see scheme). The results suggest that steric hindrance by the sugar moiety of incoming nucleotide triphosphates primarily plays an important role.

Fachgebiet (DDC)

540 Chemie

Schlagwörter

DNA polymerases, DNA recognition, DNA replication, nucleotide analogues, nucleotides

Zitieren

ISO 690

STRERATH, Michael, Daniel SUMMERER, Andreas MARX, 2002. Varied DNA Polymerase : Substrate Interactions in the Nucleotide Binding Pocket. In: ChemBioChem. 2002, 3(6), pp. 578-580. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/1439-7633(20020603)3:6<578::AID-CBIC578>3.0.CO;2-W

BibTex

@article{Strerath2002Varie-10015,
  year={2002},
  doi={10.1002/1439-7633(20020603)3:6<578::AID-CBIC578>3.0.CO;2-W},
  title={Varied DNA Polymerase : Substrate Interactions in the Nucleotide Binding Pocket},
  number={6},
  volume={3},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={578--580},
  author={Strerath, Michael and Summerer, Daniel and Marx, Andreas}
}

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Universitätsbibliographie

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