Investigation of Microcystin Congener-Dependent Uptake into Primary Murine Neurons
Dateien
Datum
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Publikationsstatus
Erschienen in
Zusammenfassung
Contamination of natural waters by toxic cyanobacteria is a growing problem worldwide, resulting in serious water pollution and human health hazards. Microcystins (MCs) represent a group of > 80 cyclic heptapeptides, mediating cytotoxicity via specific protein phosphatase (PP) inhibition at equimolar concentrations (comparable toxicodynamics). Because of the structure and size of MCs, active uptake into cells occurs via organic anion-transporting polypeptides (OATP/Oatp), as confirmed for liver-specific human OATP1B1 and OATP1B3, mouse Oatp1b2 (mOatp1b2), skate Oatp1d1, and the more widely distributed OATP1A2 expressed, for example, at the blood-brain barrier. Tissue-specific and cell-type-specific expression of OATP/Oatp transporters and specific transport of MC congeners (toxicokinetics) therefore appear prerequisite for the reported toxic effects in humans and other species upon MC exposure. Beyond hepatotoxicity induced by the MC-LR congener, the effects of other MC congeners, especially neuronal uptake and toxicity, are unknown.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
Schlagwörter
Konferenz
Rezension
Zitieren
ISO 690
FEURSTEIN, Daniel, Julia KLEINTEICH, Alexandra H. HEUSSNER, Kerstin STEMMER, Daniel R. DIETRICH, 2010. Investigation of Microcystin Congener-Dependent Uptake into Primary Murine Neurons. In: Environmental Health Perspectives. 2010, 118(10), pp. 1370-1375. eISSN 0091-6765. Available under: doi: 10.1289/ehp.0901289BibTex
@article{Feurstein2010Inves-7712, year={2010}, doi={10.1289/ehp.0901289}, title={Investigation of Microcystin Congener-Dependent Uptake into Primary Murine Neurons}, number={10}, volume={118}, journal={Environmental Health Perspectives}, pages={1370--1375}, author={Feurstein, Daniel and Kleinteich, Julia and Heussner, Alexandra H. and Stemmer, Kerstin and Dietrich, Daniel R.} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/7712"> <dc:contributor>Heussner, Alexandra H.</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Stemmer, Kerstin</dc:contributor> <dcterms:abstract>Contamination of natural waters by toxic cyanobacteria is a growing problem worldwide, resulting in serious water pollution and human health hazards. Microcystins (MCs) represent a group of > 80 cyclic heptapeptides, mediating cytotoxicity via specific protein phosphatase (PP) inhibition at equimolar concentrations (comparable toxicodynamics). Because of the structure and size of MCs, active uptake into cells occurs via organic anion-transporting polypeptides (OATP/Oatp), as confirmed for liver-specific human OATP1B1 and OATP1B3, mouse Oatp1b2 (mOatp1b2), skate Oatp1d1, and the more widely distributed OATP1A2 expressed, for example, at the blood-brain barrier. Tissue-specific and cell-type-specific expression of OATP/Oatp transporters and specific transport of MC congeners (toxicokinetics) therefore appear prerequisite for the reported toxic effects in humans and other species upon MC exposure. Beyond hepatotoxicity induced by the MC-LR congener, the effects of other MC congeners, especially neuronal uptake and toxicity, are unknown.</dcterms:abstract> <dc:creator>Dietrich, Daniel R.</dc:creator> <dc:creator>Feurstein, Daniel</dc:creator> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7712/1/Feurstein_2010.pdf"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:36:34Z</dc:date> <dc:creator>Kleinteich, Julia</dc:creator> <dcterms:issued>2010</dcterms:issued> <dc:contributor>Dietrich, Daniel R.</dc:contributor> <dc:language>eng</dc:language> <dc:contributor>Feurstein, Daniel</dc:contributor> <dc:contributor>Kleinteich, Julia</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7712"/> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7712/1/Feurstein_2010.pdf"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:36:34Z</dcterms:available> <dc:creator>Heussner, Alexandra H.</dc:creator> <dcterms:title>Investigation of Microcystin Congener-Dependent Uptake into Primary Murine Neurons</dcterms:title> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dcterms:bibliographicCitation>First publ. in: Environmental Health Perspectives 118 (2010), 10, pp. 1370-1375</dcterms:bibliographicCitation> <dc:creator>Stemmer, Kerstin</dc:creator> <dc:format>application/pdf</dc:format> <dc:rights>terms-of-use</dc:rights> </rdf:Description> </rdf:RDF>