Chaperone-assisted folding of newly synthesized proteins in the cytosol

Deuerling, Elke; Bukau, Bernd

Chaperone-assisted folding of newly synthesized proteins in the cytosol

Dateien

Chaperone_assisted_folding_of_newly_synthesized_proteins_in_the_cytosol.pdfGröße: 4.3 MBDownloads: 899

Datum

2004

Autor:innen

Deuerling, Elke

Bukau, Bernd

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Critical Reviews in Biochemistry and Molecular Biology. 2004, 39(5-6), pp. 261-277. ISSN 1040-9238. eISSN 1549-7798. Available under: doi: 10.1080/10409230490892496

Zusammenfassung

The way in which a newly synthesized polypeptide chain folds into its unique three-dimensional structure remains one of the fundamental questions in molecular biology. Protein folding in the cell is a problematic process and, in many cases, requires the assistance of a network of molecular chaperones to support productive protein folding in vivo. During protein biosynthesis, ribosome-associated chaperones guide the folding of the nascent polypeptide emerging from the ribosomal tunnel. In this review we summarize the basic principles of the protein-folding process and the involved chaperones, and focus on the role of ribosome-associated chaperones. Our discussion emphasizes the bacterial Trigger Factor, which is the best studied chaperone of this type. Recent advances have determined the atomic structure of the Trigger Factor, providing new, exciting insights into the role of ribosome-associated chaperones in co-translational protein folding.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

trigger factor, GroEL, DnaK, nascent chains, aggregation

Zitieren

ISO 690

DEUERLING, Elke, Bernd BUKAU, 2004. Chaperone-assisted folding of newly synthesized proteins in the cytosol. In: Critical Reviews in Biochemistry and Molecular Biology. 2004, 39(5-6), pp. 261-277. ISSN 1040-9238. eISSN 1549-7798. Available under: doi: 10.1080/10409230490892496

BibTex

@article{Deuerling2004Chape-7309,
  year={2004},
  doi={10.1080/10409230490892496},
  title={Chaperone-assisted folding of newly synthesized proteins in the cytosol},
  number={5-6},
  volume={39},
  issn={1040-9238},
  journal={Critical Reviews in Biochemistry and Molecular Biology},
  pages={261--277},
  author={Deuerling, Elke and Bukau, Bernd}
}

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Universitätsbibliographie

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