@article{Hauck2000Focal-8526,
  year={2000},
  doi={10.1385/IR:21:2-3:293},
  title={Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration},
  number={2/3},
  volume={21},
  issn={1931-857X},
  journal={Immunologic Research},
  pages={293--303},
  author={Hauck, Christof R. and Klingbeil, Candice K. and Schlaepfer, David D.}
}

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    <dc:contributor>Hauck, Christof R.</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:44:24Z</dcterms:available>
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    <dcterms:bibliographicCitation>First publ. in: Immunologic Research 21 (2000), 2/3, pp. 293-303</dcterms:bibliographicCitation>
    <dc:creator>Hauck, Christof R.</dc:creator>
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    <dc:creator>Klingbeil, Candice K.</dc:creator>
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    <dcterms:title>Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration</dcterms:title>
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    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:44:24Z</dc:date>
    <dc:contributor>Klingbeil, Candice K.</dc:contributor>
    <dcterms:issued>2000</dcterms:issued>
    <dc:creator>Schlaepfer, David D.</dc:creator>
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    <dcterms:abstract xml:lang="eng">In performing host-defense functions, cells of the immune system become activated by soluble chemokine signals and must migrate through endothelial cell or solid tissue barriers to reach sites of inflammation or infection. Regulated adhesive interactions of immune cells with endothelium, extracellular matrix components, and cells of solid organs are critical control points of the overall immune response. Both the soluble chemokine and cell adhesion receptor-mediated migration signals must converge on common intracellular targets to engage the cell migration machinery. In this article, we focus on the role of focal adhesion kinase (FAK) and its homolog Pyk2 as cytoplasmic mediators of motility events in multiple cell types. We introduce the overall domain structure of the FAK and Pyk2 nonreceptor protein tyrosine kinases (prKs), highlight some of the signals that activate these prKs, and detail the molecules that functionally interact and signal transduction pathwayst hat may mediate cell migration responses. Emphasis is placed on the knowledge gained from studies using FAK-null cells as a model system to decipher the role of this PTK in promoting cell motility.</dcterms:abstract>
    <dc:contributor>Schlaepfer, David D.</dc:contributor>
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