How do P-Type ATPases transport ions?

Apell, Hans-Jürgen

How do P-Type ATPases transport ions?

Dateien

How_do_P_Type_ATPases.pdfGröße: 293.94 KBDownloads: 648

Datum

2004

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Bioelectrochemistry. 2004, 63(1-2), pp. 149-156. ISSN 0302-4598. eISSN 1878-562X

Zusammenfassung

P-type ATPases are a large family of membrane proteins that perform active ion transport across biological membranes. In these proteins, the energy-providing ATP hydrolysis is coupled to ion transport of one or two ion species across the respective membrane. The pump function of the investigated pumps is described by a so-called Post-Albers cycle. Main features of the pumping process are (1) a Ping-Pong mechanism, i.e. both transported ion species are transferred successively and in opposite direction across the membrane, (2) the transport process for each ion species consists of a sequence of reaction steps, which are ion binding, ion occlusion, conformational transition of the protein, successive deocclusion of the ions and release to the other side of the membrane. (3) Recent experimental evidence shows that the ion-binding sites are placed in the transmembrane section of the proteins and that ion movements occur preferentially during the ion binding and release processes. The main features of the mechanism include narrow access channels from both sides, one gate per access channel, and an ion-binding moiety that is adapted specifically to the ions that are transported, and differently in both principal conformations.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Na, K-ATPase, Ca-ATPase, Ion transport, Electrogenicity

Zitieren

ISO 690

APELL, Hans-Jürgen, 2004. How do P-Type ATPases transport ions?. In: Bioelectrochemistry. 2004, 63(1-2), pp. 149-156. ISSN 0302-4598. eISSN 1878-562X

BibTex

@article{Apell2004PType-7863,
  year={2004},
  title={How do P-Type ATPases transport ions?},
  number={1-2},
  volume={63},
  issn={0302-4598},
  journal={Bioelectrochemistry},
  pages={149--156},
  author={Apell, Hans-Jürgen}
}

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    <dcterms:abstract xml:lang="eng">P-type ATPases are a large family of membrane proteins that perform active ion transport across biological membranes. In these proteins, the energy-providing ATP hydrolysis is coupled to ion transport of one or two ion species across the respective membrane. The pump function of the investigated pumps is described by a so-called Post-Albers cycle. Main features of the pumping process are (1) a Ping-Pong mechanism, i.e. both transported ion species are transferred successively and in opposite direction across the membrane, (2) the transport process for each ion species consists of a sequence of reaction steps, which are ion binding, ion occlusion, conformational transition of the protein, successive deocclusion of the ions and release to the other side of the membrane. (3) Recent experimental evidence shows that the ion-binding sites are placed in the transmembrane section of the proteins and that ion movements occur preferentially during the ion binding and release processes. The main features of the mechanism include narrow access channels from both sides, one gate per access channel, and an ion-binding moiety that is adapted specifically to the ions that are transported, and differently in both principal conformations.</dcterms:abstract>
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Universitätsbibliographie

Ja