Potassium channel structures: do they conform?

Gulbis, Jacqueline; Doyle, Declan

Potassium channel structures: do they conform?

Dateien

Potassium_channel_structures.pdfGröße: 599.84 KBDownloads: 642

Datum

2004

Autor:innen

Gulbis, Jacqueline

Doyle, Declan

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Current Opinion in Structural Biology. 2004, 14(4), pp. 440-446. ISSN 0959-440X. Available under: doi: 10.1016/j.sbi.2004.06.008

Zusammenfassung

Potassium channels are signalling elements vital to vertebrate neurotransmission, and cardiac and renal function. Two inherent qualities equip them for their role in the interconversion of chemical and electrical messages: high selectivity for potassium ions and the ability to open (gate) on cue. The crystal structure of KcsA, published in 1998, explained much about potassium selectivity and high ion flux. The enormous diversity of potassium channels (some hundreds of genes in humans) may have hampered similar progress in understanding gating processes. The recent determination of several representative structures has provided us with a valuable reference for discriminating between features that are utilized in gating across the potassium channel genre and features that determine responsiveness to familyspecific gating cues.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

GULBIS, Jacqueline, Declan DOYLE, 2004. Potassium channel structures: do they conform?. In: Current Opinion in Structural Biology. 2004, 14(4), pp. 440-446. ISSN 0959-440X. Available under: doi: 10.1016/j.sbi.2004.06.008

BibTex

@article{Gulbis2004Potas-8393,
  year={2004},
  doi={10.1016/j.sbi.2004.06.008},
  title={Potassium channel structures: do they conform?},
  number={4},
  volume={14},
  issn={0959-440X},
  journal={Current Opinion in Structural Biology},
  pages={440--446},
  author={Gulbis, Jacqueline and Doyle, Declan}
}

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