A microscopic model for the current-voltage behaviour of the Na,K-pump

Läuger, Peter; Apell, Hans-Jürgen

A microscopic model for the current-voltage behaviour of the Na,K-pump

Dateien

A_microscopic_model_for_the_current_voltage_behaviour_of_the_Na_K_pump.pdfGröße: 2.1 MBDownloads: 349

Datum

1986

Autor:innen

Läuger, Peter

Apell, Hans-Jürgen

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

European Biophysics Journal. 1986, 13(5), pp. 309-321. ISSN 0175-7571. eISSN 1432-1017. Available under: doi: 10.1007/BF00254213

Zusammenfassung

The current voltage characteristic of the Na, K pump is described on the basis of a modified Post-Albers cycle. The voltage dependence of the rate constants is derived from the elementary chargetranslocations associated with the single reaction steps. Charge displacements result from movements of the sodium- or potassium-loaded binding sites, as well as from motions of polar groups in the pump molecule. If part of the transmembrane voltage drops between the alkali-ion binding sites and the aqueous solution, the binding constants become voltage-dependent. Depending on the values of the microscopic parameters, the current-voltage characteristic may assume a variety of different shapes. Saturating behaviour results when one or more voltage-independent reaction steps become rate limiting. Non-monotonic current-voltage curves exhibiting regions of negative pump conductance are predicted when, at least in one of the transitiops, charge is moved against. the direction of overall charge-translocation. The theoretical predictions are compared with recent experimental studies of voltage-dependent pump currents.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Na,K-pump, active transport, electrogenic transport, current-voltage behaviour, Post-Albers scheme

Zitieren

ISO 690

LÄUGER, Peter, Hans-Jürgen APELL, 1986. A microscopic model for the current-voltage behaviour of the Na,K-pump. In: European Biophysics Journal. 1986, 13(5), pp. 309-321. ISSN 0175-7571. eISSN 1432-1017. Available under: doi: 10.1007/BF00254213

BibTex

@article{Lauger1986micro-6920,
  year={1986},
  doi={10.1007/BF00254213},
  title={A microscopic model for the current-voltage behaviour of the Na,K-pump},
  number={5},
  volume={13},
  issn={0175-7571},
  journal={European Biophysics Journal},
  pages={309--321},
  author={Läuger, Peter and Apell, Hans-Jürgen}
}

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