Temporary attachment of carbohydrates to cyclopeptide templates : a new strategy for single-bead analysis of multivalent neoglycopeptides

Wittmann, Valentin; Seeberger, Sonja; Schägger, Hermann

Temporary attachment of carbohydrates to cyclopeptide templates : a new strategy for single-bead analysis of multivalent neoglycopeptides

Dateien

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Datum

2003

Autor:innen

Wittmann, Valentin

Seeberger, Sonja

Schägger, Hermann

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Chemie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Tetrahedron Letters. 2003, 44(52), pp. 9243-9246. ISSN 0040-4039. Available under: doi: 10.1016/j.tetlet.2003.10.078

Zusammenfassung

Employing a cleavable carbohydrate peptide linker, a new strategy for single-bead analysis of multivalent cyclic neoglycopeptides based on Edman degradation is described. Edman degradation of glycopeptides is hampered by the acid lability of the glycosidic bond and potential incompatibilities of phenylthiohydantoin (PTH) derivatives of glycosylated amino acids with PTH derivatives of the proteinogenic amino acids. To overcome this problem, carbohydrates are detached from the cyclopeptide templates before single-bead analysis, allowing for micro sequencing under routine conditions. With this strategy, application of multivalent cyclic neoglycopeptides in split-mix libraries with a subsequent screening process becomes possible for the first time.

Fachgebiet (DDC)

540 Chemie

Zitieren

ISO 690

WITTMANN, Valentin, Sonja SEEBERGER, Hermann SCHÄGGER, 2003. Temporary attachment of carbohydrates to cyclopeptide templates : a new strategy for single-bead analysis of multivalent neoglycopeptides. In: Tetrahedron Letters. 2003, 44(52), pp. 9243-9246. ISSN 0040-4039. Available under: doi: 10.1016/j.tetlet.2003.10.078

BibTex

@article{Wittmann2003Tempo-9750,
  year={2003},
  doi={10.1016/j.tetlet.2003.10.078},
  title={Temporary attachment of carbohydrates to cyclopeptide templates : a new strategy for single-bead analysis of multivalent neoglycopeptides},
  number={52},
  volume={44},
  issn={0040-4039},
  journal={Tetrahedron Letters},
  pages={9243--9246},
  author={Wittmann, Valentin and Seeberger, Sonja and Schägger, Hermann}
}

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Universitätsbibliographie

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