Novel strategies for the site-specific covalent labelling of nucleic acids

Weisbrod, Samuel H.; Marx, Andreas

Novel strategies for the site-specific covalent labelling of nucleic acids

Dateien

Weisbrod_Chem_Comm_2008.pdfGröße: 1.82 MBDownloads: 773

Datum

2008

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Chemie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Chemical communications. 2008(44), pp. 5675-5685. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/B809528K

Zusammenfassung

To broaden the scope of applications in DNA nano- and biotechnology, material science, diagnostics and molecular recognition the functionalization of DNA is of utmost importance. In the last decade many new methods have been developed to achieve this goal. Apart from the direct chemical synthesis of modified DNA by automated phosphoramidite chemistry incorporation of labelled triphosphates and the post-synthetic labelling approach evolved as valuable methods. New bioorthogonal reactions as Diels Alder, click and Staudinger ligations pushed forward the post-synthetic approach as new insights into DNA polymerase substrate specifity allowed generation and amplification of labelled DNA strands. These novel developments are summarized herein.

Fachgebiet (DDC)

540 Chemie

Zitieren

ISO 690

WEISBROD, Samuel H., Andreas MARX, 2008. Novel strategies for the site-specific covalent labelling of nucleic acids. In: Chemical communications. 2008(44), pp. 5675-5685. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/B809528K

BibTex

@article{Weisbrod2008Novel-9682,
  year={2008},
  doi={10.1039/B809528K},
  title={Novel strategies for the site-specific covalent labelling of nucleic acids},
  number={44},
  issn={1359-7345},
  journal={Chemical communications},
  pages={5675--5685},
  author={Weisbrod, Samuel H. and Marx, Andreas}
}

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Universitätsbibliographie

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