Poly(ADP-ribose) polymerase activity in different pathologies : the link to inflammation and infarction
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DNA repair and aging are two phenomena closely connected to each other. The poly(ADP-ribosyl)ation reaction has been implicated in both of them. Poly(ADP-ribose) was originally discovered as an enzymatic reaction product after DNA damage. Soon it became evident that it is necessary for regulation of different repair pathways. Also, evidence accumulated that poly(ADP-ribose) formation capacity is at least correlated with the life span of mammalian species. As a NAD+-consuming process, poly(ADP-ribosyl)ation can lead to cell death by energy depletion. This finding opened the area for investigation of poly(ADP-ribose) polymerase activity and polymer formation in pathologies. This review provides an introduction into the wide and complex field of poly(ADP-ribosyl)ation in different pathologies with regards of cell death regulation, inflammation and resulting tissue damage.
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BENEKE, Sascha, 2008. Poly(ADP-ribose) polymerase activity in different pathologies : the link to inflammation and infarction. In: Experimental Gerontology. 2008, 43(7), pp. 605-614. ISSN 0531-5565. Available under: doi: 10.1016/j.exger.2008.04.008BibTex
@article{Beneke2008PolyA-7387, year={2008}, doi={10.1016/j.exger.2008.04.008}, title={Poly(ADP-ribose) polymerase activity in different pathologies : the link to inflammation and infarction}, number={7}, volume={43}, issn={0531-5565}, journal={Experimental Gerontology}, pages={605--614}, author={Beneke, Sascha} }
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