@article{Kunzmann2007Effec-8768,
  year={2007},
  doi={10.1016/j.exger.2007.10.003},
  title={Effect of zinc on cellular poly(ADP-ribosyl)ation capacity},
  number={5},
  volume={43},
  issn={0531-5565},
  journal={Experimental Gerontology},
  pages={409--414},
  author={Kunzmann, Andrea and Dedoussis, George and Jajte, Jolanta and Malavolta, Marco and Mocchegiani, Eugenio and Bürkle, Alexander}
}

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    <dc:creator>Dedoussis, George</dc:creator>
    <dcterms:bibliographicCitation>First publ. in: Experimental Gerontology 43 (2008), 5, pp. 409-414</dcterms:bibliographicCitation>
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    <dc:creator>Malavolta, Marco</dc:creator>
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    <dc:creator>Kunzmann, Andrea</dc:creator>
    <dc:contributor>Jajte, Jolanta</dc:contributor>
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    <dc:contributor>Dedoussis, George</dc:contributor>
    <dc:creator>Mocchegiani, Eugenio</dc:creator>
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    <dc:creator>Jajte, Jolanta</dc:creator>
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    <dc:contributor>Mocchegiani, Eugenio</dc:contributor>
    <dc:contributor>Bürkle, Alexander</dc:contributor>
    <dcterms:abstract xml:lang="eng">Poly(ADP-ribosyl)ation is a posttranslational protein modification, which is catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1) and plays a role in DNA repair and maintenance of genomic stability. A decrease in cellular poly(ADP-ribosyl)ation has been implicated in the aging process. As PARP-1 is a zinc finger protein its decreased function might be related to age-related zinc deficiency. To test this hypothesis we assessed cellular poly(ADP-ribosyl)ation capacity in 29 donors from Greece, Italy and Poland as function of age and nutritional zinc status. Our results reveal a positive correlation between cellular poly(ADP-ribosyl)ation capacity and zinc status in human peripheral blood mononuclear cells (PBMC) (p &lt; 0.05). We could also confirm a decrease of PARP-1 activity with donor age, highlighting the role of poly(ADP-ribosyl)ation in the aging process. The results demonstrate that zinc supplementation in elderly people can increase the cellular poly(ADP-ribosyl)ation capacity of their PBMC. We speculate that this may help maintain integrity and stability of the genome more efficiently and thus contribute to an extension of healthspan.</dcterms:abstract>
    <dc:creator>Bürkle, Alexander</dc:creator>
    <dcterms:title>Effect of zinc on cellular poly(ADP-ribosyl)ation capacity</dcterms:title>
    <dc:contributor>Kunzmann, Andrea</dc:contributor>
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