Lysosomes in cell death

Guicciardi, Maria Eugenia; Leist, Marcel; Gores, Gregory J.

Lysosomes in cell death

Dateien

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Datum

2004

Autor:innen

Guicciardi, Maria Eugenia

Leist, Marcel

Gores, Gregory J.

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Oncogene. 2004, 23(16), pp. 2881-2890. ISSN 0950-9232. eISSN 1476-5594. Available under: doi: 10.1038/sj.onc.1207512

Zusammenfassung

For many years apoptosis research has focused on caspases and their putative role as sole executioners of programmed cell death. Accumulating information now suggests that lysosomal cathepsins are also pivotally involved in this process, especially in pathological conditions. In particular, the role of lysosomes and lysosomal enzymes in initiation and execution of the apoptotic program has become clear in several models, to the point that the existence of a 'lysosomal pathway of apoptosis' is now generally accepted. This pathway of apoptosis can be activated by death receptors, lipid mediators, and photodamage. Lysosomal proteases can be released from the lysosomes into the cytosol, where they contribute to the apoptotic cascade upstream of mitochondria. This review focuses on the players and the molecular mechanisms involved in the lysosomal pathway of apoptosis as well as on the importance of this pathway in development and pathology.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

cathepsins, Spi2A, TNFalpha

Zitieren

ISO 690

GUICCIARDI, Maria Eugenia, Marcel LEIST, Gregory J. GORES, 2004. Lysosomes in cell death. In: Oncogene. 2004, 23(16), pp. 2881-2890. ISSN 0950-9232. eISSN 1476-5594. Available under: doi: 10.1038/sj.onc.1207512

BibTex

@article{Guicciardi2004Lysos-8037,
  year={2004},
  doi={10.1038/sj.onc.1207512},
  title={Lysosomes in cell death},
  number={16},
  volume={23},
  issn={0950-9232},
  journal={Oncogene},
  pages={2881--2890},
  author={Guicciardi, Maria Eugenia and Leist, Marcel and Gores, Gregory J.}
}

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