Activating the ubiquitin family : UBA6 challenges the field

Gröttrup, Marcus; Pelzer, Christiane; Schmidtke, Gunter; Hofmann, Kay

Activating the ubiquitin family : UBA6 challenges the field

Dateien

Groettrup_opus-85098.pdfGröße: 701.53 KBDownloads: 924

Datum

2008

Autor:innen

Gröttrup, Marcus

Pelzer, Christiane

Schmidtke, Gunter

Hofmann, Kay

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Trends in Biochemical Sciences. 2008, 33(5), pp. 230-237. ISSN 0968-0004. Available under: doi: 10.1016/j.tibs.2008.01.005

Zusammenfassung

Since its discovery in 1981, ubiquitin-activating enzyme 1 was thought to be the only E1-type enzyme responsible for ubiquitin activation. Recently, a relatively uncharacterized E1 enzyme, designated ubiquitin-like modifier activating enzyme 6, was also shown to activate ubiquitin. Ubiquitin-activating enzyme 1 and ubiquitin-like modifier activating enzyme 6 are both essential proteins, and each uses a different spectrum of ubiquitin-conjugating (E2) enzymes. Ubiquitin-like modifier activating enzyme 6 activates not only ubiquitin, but also the ubiquitin-like modifier FAT10 (human leukocyte antigen F-associated transcript 10), which, similarly to ubiquitin, serves as a signal for proteasomal degradation. This new layer of regulation in ubiquitin activation markedly increases the versatility of the ubiquitin conjugation system.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

GRÖTTRUP, Marcus, Christiane PELZER, Gunter SCHMIDTKE, Kay HOFMANN, 2008. Activating the ubiquitin family : UBA6 challenges the field. In: Trends in Biochemical Sciences. 2008, 33(5), pp. 230-237. ISSN 0968-0004. Available under: doi: 10.1016/j.tibs.2008.01.005

BibTex

@article{Grottrup2008Activ-1200,
  year={2008},
  doi={10.1016/j.tibs.2008.01.005},
  title={Activating the ubiquitin family : UBA6 challenges the field},
  number={5},
  volume={33},
  issn={0968-0004},
  journal={Trends in Biochemical Sciences},
  pages={230--237},
  author={Gröttrup, Marcus and Pelzer, Christiane and Schmidtke, Gunter and Hofmann, Kay}
}

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Universitätsbibliographie

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