Universität zu Köln

Ubelmesser, Nadine and Papantonis, Argyris ORCID: 0000-0001-7551-1073 (2019). Technologies to study spatial genome organization: beyond 3C. Brief. Funct. Genomics, 18 (6). S. 395 - 402. OXFORD: OXFORD UNIV PRESS. ISSN 2041-2657

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Abstract

The way that chromatin is organized in three-dimensional nuclear space is now acknowledged as a factor critical for the major cell processes, like transcription, replication and cell division. Researchers have been armed with new molecular and imaging technologies to study this structure-to-function link of genomes, spearheaded by the introduction of the 'chromosome conformation capture' technology more than a decade ago. However, this technology is not without shortcomings, and novel variants and orthogonal approaches are being developed to overcome these. As a result, the field of nuclear organization is constantly fueled by methods of increasing resolution and/or throughput that strive to eliminate systematic biases and increase precision. In this review, we attempt to highlight the most recent advances in technology that promise to provide novel insights on how chromosomes fold and function.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ubelmesser, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Papantonis, Argyris UNSPECIFIED orcid.org/0000-0001-7551-1073 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-128441
DOI:	10.1093/bfgp/elz019
Journal or Publication Title:	Brief. Funct. Genomics
Volume:	18
Number:	6
Page Range:	S. 395 - 402
Date:	2019
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	2041-2657
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHROMATIN DOMAINS; CHROMOSOME TERRITORIES; PROXIMITY-LIGATION; CROSS-LINKING; REVEALS; ARCHITECTURE; PRINCIPLES; IDENTIFICATION; LANDSCAPE Multiple languages Biotechnology & Applied Microbiology; Genetics & Heredity Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12844