Universität zu Köln

Xiong, Qiuhong, Li, Wenjing, Li, Ping, Yang, Min, Wu, Changxin and Eichinger, Ludwig ORCID: 0000-0003-1594-6117 (2019). The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System. Cells, 8 (1). BASEL: MDPI. ISSN 2073-4409

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Abstract

Autophagy and the ubiquitin proteasome system (UPS) are the two major cellular degradation pathways, which are critical for the maintenance of cell homeostasis. The two pathways differ in their mechanisms and clients. The evolutionary conserved ATG16 plays a key role in autophagy and appears to link autophagy with the UPS. Here, we review the role of ATG16 in different species. We summarize the current knowledge of its functions in autophagosome membrane expansion and autophagosome formation, in Crohn's disease, and in bacterial sequestration. In addition, we provide information on its autophagy-independent functions and its role in the crosstalk between autophagy and the UPS.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Xiong, Qiuhong UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Wenjing UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Ping UNSPECIFIED UNSPECIFIED UNSPECIFIED Yang, Min UNSPECIFIED UNSPECIFIED UNSPECIFIED Wu, Changxin UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichinger, Ludwig UNSPECIFIED orcid.org/0000-0003-1594-6117 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-139594
DOI:	10.3390/cells8010002
Journal or Publication Title:	Cells
Volume:	8
Number:	1
Date:	2019
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2073-4409
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GENOME-WIDE ASSOCIATION; PLASMA-MEMBRANE; CROHNS-DISEASE; WD-REPEAT; SELECTIVE AUTOPHAGY; SUSCEPTIBILITY LOCI; CANONICAL AUTOPHAGY; ULK1 COMPLEX; PROTEIN; DEGRADATION Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13959