Universität zu Köln

Bilstein, Andreas ORCID: 0000-0002-1849-2520, Unfried, Klaus, Shah-Hosseini, Kija ORCID: 0000-0001-9616-6942 and Moesges, Ralph (2019). Ectoine-Containing Inhalation Solution versus Saline Inhalation Solution in the Treatment of Acute Bronchitis and Acute Respiratory Infections: A Prospective, Controlled, Observational Study. Biomed Res. Int., 2019. LONDON: HINDAWI LTD. ISSN 2314-6141

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Abstract

Purpose. This study investigated an inhalation solution containing ectoine, a bacterial-derived extremolyte, for the treatment of acute bronchitis and acute respiratory infections in comparison with saline inhalation solution. Methods. This prospective, controlled, observational study comprised an inclusion visit (day 1), a final visit (day 7), and a follow-up questionnaire (day 17). The treatment itself was administered from day 1 to day 7. The Bronchitis Severity Score, patients' general health, general effectiveness of the treatment, tolerability, and adverse events were compared between two groups. Results. In total, 135 patients were recruited; 79 patients received ectoine inhalation solution and 56 saline inhalation solution. After treatment, symptom scores decreased significantly in both groups (P < 0.05); the reduction in symptom scores was slightly greater in the ectoine group than in the saline group. The first significant reduction in symptom scores (P < 0.05) occurred earlier in the ectoine group than in the saline group. The differences in the area under the curve for the symptoms of dyspnea and auscultation findings were significant in favor of ectoine (P < 0.05). After treatment, more patients and physicians in the ectoine group assessed their or their patients' condition as completely recovered or greatly improved than those in the saline group. Almost all patients and physicians assessed the tolerability of both treatments as good or very good. Conclusions. Ectoine inhalation solution seems to be slightly more effective than saline inhalation solution for the treatment of acute bronchitis and acute respiratory infections.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bilstein, Andreas UNSPECIFIED orcid.org/0000-0002-1849-2520 UNSPECIFIED Unfried, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah-Hosseini, Kija UNSPECIFIED orcid.org/0000-0001-9616-6942 UNSPECIFIED Moesges, Ralph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-139792
DOI:	10.1155/2019/7945091
Journal or Publication Title:	Biomed Res. Int.
Volume:	2019
Date:	2019
Publisher:	HINDAWI LTD
Place of Publication:	LONDON
ISSN:	2314-6141
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HERBAL DRUG PREPARATION; DOUBLE-BLIND; LUNG INFLAMMATION; THYME HERB; PLACEBO; TOLERABILITY; EFFICACY; ADULTS; EXTREMOPHILES; COMBINATION Multiple languages Biotechnology & Applied Microbiology; Medicine, Research & Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13979