von Bismarck, Olga, Dankowski, Theresa, Ambrosius, Bjeorn, Hessler, Nicole, Antony, Gisela, Ziegler, Andreas ORCID: 0000-0002-8386-5397, Hoshi, Muna-Miriam, Aly, Lilian ORCID: 0000-0002-7051-124X, Luessi, Felix, Groppa, Sergiu ORCID: 0000-0002-2551-5655, Klotz, Luisa, Meuth, Sven G., Tackenberg, Bjorn, Stoppe, Muriel, Bergh, Florian Then, Tumani, Hayrettin, Kuempfel, Tania, Stangel, Martin, Heesen, Christoph, Wildemann, Brigitte, Paul, Friedemann, Bayas, Antonios, Warnke, Clemens, Weber, Frank, Linker, Ralf A., Ziemann, Ulf, Zettl, Uwe K., Zipp, Frauke ORCID: 0000-0002-1231-1928, Wiendl, Heinz ORCID: 0000-0003-4310-3432, Hemmer, Bernhard, Gold, Ralf and Salmen, Anke ORCID: 0000-0002-4751-299X (2018). Treatment choices and neuropsychological symptoms of a large cohort of early MS. Neurol.-Neuroimmunol. Neuroinflammation, 5 (3). PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 2332-7812

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Abstract

Objective To assess clinical characteristics, distribution of disease-modifying treatments (DMTs), and neuropsychological symptoms in a large cohort of patients with early-stage MS. Methods The German National MS Cohort is a multicenter prospective longitudinal cohort study that has recruited DMT-naive patients with clinically isolated syndrome (CIS) and relapsing-remitting MS (RRMS) since 2010. We evaluated their baseline characteristics and the prevalence of neuropsychological symptoms. Results Of 1,124 patients, with a 2.2: 1 female-to-male ratio and median age at onset of 31.71 years (interquartile range [IQR]: 26.06-40.33), 44.6% and 55.3% had CIS and RRMS, respectively. The median Expanded Disability Status Scale (EDSS) score at baseline was 1.5 (IQR: 1.0-2.0). A proportion of 67.8% of patients started DMT after a median time of 167.0 days (IQR 90.0-377.5) since the first manifestation. A total of 64.7% and 70.4% of the 762 patients receiving early DMT were classified as CIS and RRMS, respectively. Fatigue, depressive symptoms, and cognitive dysfunction were detected in 36.5%, 33.5%, and 14.7% of patients, respectively. Conclusion Baseline characteristics of this large cohort of patients with early, untreated MS corroborated with other cohorts. Most patients received early DMT within the first year after disease onset, irrespective of a CIS or RRMS diagnosis. Despite the low EDSS score, neuropsychological symptoms affected a relevant proportion of patients.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
von Bismarck, OlgaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dankowski, TheresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ambrosius, BjeornUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hessler, NicoleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antony, GiselaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ziegler, AndreasUNSPECIFIEDorcid.org/0000-0002-8386-5397UNSPECIFIED
Hoshi, Muna-MiriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aly, LilianUNSPECIFIEDorcid.org/0000-0002-7051-124XUNSPECIFIED
Luessi, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Groppa, SergiuUNSPECIFIEDorcid.org/0000-0002-2551-5655UNSPECIFIED
Klotz, LuisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meuth, Sven G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tackenberg, BjornUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoppe, MurielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bergh, Florian ThenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tumani, HayrettinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuempfel, TaniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stangel, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heesen, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wildemann, BrigitteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paul, FriedemannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bayas, AntoniosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Warnke, ClemensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Linker, Ralf A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ziemann, UlfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zettl, Uwe K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zipp, FraukeUNSPECIFIEDorcid.org/0000-0002-1231-1928UNSPECIFIED
Wiendl, HeinzUNSPECIFIEDorcid.org/0000-0003-4310-3432UNSPECIFIED
Hemmer, BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gold, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salmen, AnkeUNSPECIFIEDorcid.org/0000-0002-4751-299XUNSPECIFIED
URN: urn:nbn:de:hbz:38-187408
DOI: 10.1212/NXI.0000000000000446
Journal or Publication Title: Neurol.-Neuroimmunol. Neuroinflammation
Volume: 5
Number: 3
Date: 2018
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 2332-7812
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
QUALITY-OF-LIFE; MULTIPLE-SCLEROSIS; GENERAL-POPULATION; CHRONIC FATIGUE; DEPRESSION; DISABILITY; IMPACT; RISK; IMPAIRMENT; CRITERIAMultiple languages
Clinical Neurology; NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18740

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