Universität zu Köln

Paeger, Lars ORCID: 0000-0001-8716-3483, Karakasilioti, Ismene, Altmueller, Janine, Frommole, Peter, Bruening, Jens and Kloppenburg, Peter (2017). Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin. eLife, 6. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

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Abstract

In the arcuate nucleus of the hypothalamus (ARH) satiety signaling (anorexigenic) proopiomelanocortin (POMC)-expressing and hunger signaling (orexigenic) agouti-related peptide (AgRP)-expressing neurons are key components of the neuronal circuits that control food intake and energy homeostasis. Here, we assessed whether the catecholamine noradrenalin directly modulates the activity of these neurons in mice. Perforated patch clamp recordings showed that noradrenalin changes the activity of these functionally antagonistic neurons in opposite ways, increasing the activity of the orexigenic NPY/AgRP neurons and decreasing the activity of the anorexigenic POMC neurons. Cell type-specific transcriptomics and pharmacological experiments revealed that the opposing effect on these neurons is mediated by the activation of excitatory alpha(1A)- and beta- adrenergic receptors in NPY/AgRP neurons, while POMC neurons are inhibited via alpha(2A) adrenergic receptors. Thus, the coordinated differential modulation of the key hypothalamic neurons in control of energy homeostasis assigns noradrenalin an important role to promote feeding.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Paeger, Lars UNSPECIFIED orcid.org/0000-0001-8716-3483 UNSPECIFIED Karakasilioti, Ismene UNSPECIFIED UNSPECIFIED UNSPECIFIED Altmueller, Janine UNSPECIFIED UNSPECIFIED UNSPECIFIED Frommole, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruening, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Kloppenburg, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-227548
DOI:	10.7554/eLife.25770
Journal or Publication Title:	eLife
Volume:	6
Date:	2017
Publisher:	ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication:	CAMBRIDGE
ISSN:	2050-084X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LEPTIN INHIBITS NOREPINEPHRINE; NORADRENERGIC LOCUS-COERULEUS; BETA-ADRENERGIC-RECEPTORS; ENERGY HOMEOSTASIS; PROOPIOMELANOCORTIN NEURONS; FUNCTIONAL NEUROANATOMY; AGRP NEURONS; HYPOTHALAMIC NEURONS; GLUCOSE-HOMEOSTASIS; DOPAMINE RELEASE Multiple languages Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22754