Universität zu Köln

Bschor, Tom and Kilarski, Laura L. (2016). Are antidepressants effective? A debate on their efficacy for the treatment of major depression in adults. Expert Rev. Neurother., 16 (4). S. 367 - 375. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1744-8360

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Abstract

Recently, the efficacy of antidepressants, a treatment used by 11% of US American adults, has been debated. Thousands of randomized controlled trials (RCTs) have been used to study antidepressants, with the majority demonstrating at least moderate superiority over placebo. In contrast, studies have found antidepressant effects to be unspecific and mainly resulting from placebo. The effects of antidepressants may also be overestimated due to selective publishing and selection of patients who have a high chance of response in RCTs. Studies have also shown the drugs do not reduce suicidal events when compared to placebo, and efficacy differences to placebo are often too small to prove clinical relevance. Here, we review the claims for and against antidepressant efficacy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bschor, Tom UNSPECIFIED UNSPECIFIED UNSPECIFIED Kilarski, Laura L. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-278928
DOI:	10.1586/14737175.2016.1155985
Journal or Publication Title:	Expert Rev. Neurother.
Volume:	16
Number:	4
Page Range:	S. 367 - 375
Date:	2016
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1744-8360
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RANDOMIZED CONTROLLED-TRIALS; SEROTONIN REUPTAKE INHIBITORS; PSYCHIATRY WFSBP GUIDELINES; CLINICAL-TRIALS; SUICIDE RATES; BIOLOGICAL TREATMENT; SYMPTOM REDUCTION; WORLD FEDERATION; PLACEBO; DISORDERS Multiple languages Clinical Neurology; Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27892