Universität zu Köln

Walter, Robert Fred Henry, Mairinger, Fabian Dominik, Werner, Robert, Ting, Saskia ORCID: 0000-0003-1415-7714, Vollbrecht, Claudia ORCID: 0000-0002-0861-001X, Theegarten, Dirk, Christoph, Daniel Christian, Zarogoulidis, Konstantinos, Schmid, Kurt Werner, Zarogoulidis, Paul and Wohlschlaeger, Jeremias (2015). SOX4, SOX11 and PAX6 mRNA expression was identified as a (prognostic) marker for the aggressiveness of neuroendocrine tumors of the lung by using next-generation expression analysis (NanoString). Future Oncol., 11 (7). S. 1027 - 1037. LONDON: FUTURE MEDICINE LTD. ISSN 1744-8301

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Abstract

Background: Neuroendocrine tumors of the lung (NELC) account for 25% of all lung cancer cases and transcription factors may drive dedifferentiation of these tumors. This study was conducted to identify supportive diagnostic and prognostic biomarkers. Materials & methods: A total of 16 TC, 13 AC, 16 large cell neuroendocrine carcinomas and 15 small cell lung cancer were investigated for the mRNA expression of 11 transcription factors and related genes (MYB, MYBBP1A, OCT4, PAX6, PCDHB, RBP1, SDCBP, SOX2, SOX4, SOX11, TEAD2). Results:SOX4 (p = 0.0002), SOX11 (p < 0.0001) and PAX6 (p = 0.0002) were significant for tumor type. Elevated PAX6 and SOX11 expression correlated with poor outcome in large cell neuroendocrine carcinomas and small cell lung cancer (p < 0.0001 and p = 0.0232, respectively) based on survival data of 34 patients (57%). Conclusion: Aggressiveness of NELC correlated with increasing expression of transcription factors. SOX11 seems to be a highly valuable diagnostic and prognostic marker for aggressive NELC.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Walter, Robert Fred Henry UNSPECIFIED UNSPECIFIED UNSPECIFIED Mairinger, Fabian Dominik UNSPECIFIED UNSPECIFIED UNSPECIFIED Werner, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Ting, Saskia UNSPECIFIED orcid.org/0000-0003-1415-7714 UNSPECIFIED Vollbrecht, Claudia UNSPECIFIED orcid.org/0000-0002-0861-001X UNSPECIFIED Theegarten, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Christoph, Daniel Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Zarogoulidis, Konstantinos UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmid, Kurt Werner UNSPECIFIED UNSPECIFIED UNSPECIFIED Zarogoulidis, Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Wohlschlaeger, Jeremias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-416876
DOI:	10.2217/fon.15.18
Journal or Publication Title:	Future Oncol.
Volume:	11
Number:	7
Page Range:	S. 1027 - 1037
Date:	2015
Publisher:	FUTURE MEDICINE LTD
Place of Publication:	LONDON
ISSN:	1744-8301
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GENE-EXPRESSION; CANCER; CLASSIFICATION; PROLIFERATION; NEUROGENESIS; CARCINOMA; SURVIVAL; FAMILY; NODE Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41687