Collisson, Eric A., Campbell, Joshua D., Brooks, Angela N., Berger, Alice H., Lee, William 
ORCID: 0000-0001-9582-4413, Chmielecki, Juliann, Beer, David G., Cope, Leslie, Creighton, Chad J., Danilova, Ludmila, Ding, Li, Getz, Gad, Hammerman, Peter S., Hayes, D. Neil, Hernandez, Bryan, Herman, James G., Heymach, John V., Jurisica, Igor, Kucherlapati, Raju, Kwiatkowski, David, Ladanyi, Marc, Robertson, Gordon, Schultz, Nikolaus ORCID: 0000-0002-0131-4904, Shen, Ronglai, Sinha, Rileen ORCID: 0000-0001-5497-5055, Sougnez, Carrie, Tsao, Ming-Sound, Travis, William D., Weinstein, John N., Wigle, Dennis A., Wilkerson, Matthew D., Chu, Andy, Cherniack, Andrew D. ORCID: 0000-0003-0470-0111, Hadjipanayis, Angela, Rosenberg, Mara ORCID: 0000-0001-6400-3161, Weisenberger, Daniel J., Laird, Peter W., Radenbaugh, Amie, Ma, Singer, Stuart, Joshua M., Byers, Lauren Averett, Baylin, Stephen B., Govindan, Ramaswamy, Meyerson, Matthew ORCID: 0000-0002-9133-8108, Rosenberg, Mara ORCID: 0000-0001-6400-3161, Gabriel, Stacey B., Cibulskis, Kristian, Sougnez, Carrie, Kim, Jaegil, Stewart, Chip, Lichtenstein, Lee, Lander, Eric S., Lawrence, Michael S., Kandoth, Cyriac ORCID: 0000-0002-1345-3573, Fulton, Robert, Fulton, Lucinda L., McLellan, Michael D., Wilson, Richard K. ORCID: 0000-0002-1992-1358, Ye, Kai, Fronick, Catrina C., Maher, Christopher A., Miller, Christopher A., Wendl, Michael C., Cabanski, Christopher, Ding, Li, Mardis, Elaine, Govindan, Ramaswamy, Creighton, Chad J., Wheeler, David, Balasundaram, Miruna, Butterfield, Yaron S. N., Carlsen, Rebecca, Chu, Andy, Chuah, Eric, Dhalla, Noreen, Guin, Ranabir, Hirst, Carrie, Lee, Darlene, Li, Haiyan I., Mayo, Michael, Moore, Richard A., Mungall, Andrew J. ORCID: 0000-0002-0905-2742, Schein, Jacqueline E., Sipahimalani, Payal, Tam, Angela, Varhol, Richard, Robertson, A. Gordon, Wye, Natasja, Thiessen, Nina, Holt, Robert A., Jones, Steven J. M., Marra, Marco A., Campbell, Joshua D., Brooks, Angela N., Chmielecki, Juliann, Imielinski, Marcin, Onofrio, Robert C., Hodis, Eran, Zack, Travis, Sougnez, Carrie, Helman, Elena, Pedamallu, Chandra Sekhar, Mesirov, Jill, Cherniack, Andrew D. ORCID: 0000-0003-0470-0111, Saksena, Gordon, Schumacher, Steven E., Carter, Scott L., Hernandez, Bryan, Garraway, Levi, Beroukhim, Rameen, Gabriel, Stacey B., Getz, Gad, Meyerson, Matthew ORCID: 0000-0002-9133-8108, Hadjipanayis, Angela, Lee, Semin ORCID: 0000-0002-9015-6046, Mahadeshwar, Harshad S., Pantazi, Angeliki, Protopopov, Alexei, Ren, Xiaojia, Seth, Sahil ORCID: 0000-0003-4579-3959, Song, Xingzhi, Tang, Jiabin, Yang, Lixing, Zhang, Jianhua, Chen, Peng-Chieh, Parfenov, Michael, Xu, Andrew Wei, Santoso, Netty, Chin, Lynda, Park, Peter J., Kucherlapati, Raju, Hoadley, Katherine A., Auman, J. Todd, Meng, Shaowu, Shi, Yan, Buda, Elizabeth, Waring, Scot, Veluvolu, Umadevi, Tan, Donghui, Mieczkowski, Piotr A., Jones, Corbin D., Simons, Janae V., Soloway, Matthew G., Bodenheimer, Tom, Jefferys, Stuart R., Roach, Jeffrey, Hoyle, Alan P., Wu, Junyuan, Balu, Saianand, Singh, Darshan, Prins, Jan F., Marron, J. S., Parker, Joel S., Hayes, D. Neil, Perou, Charles M., Liu, Jinze, Cope, Leslie, Danilova, Ludmila, Weisenberger, Daniel J., Maglinte, Dennis T., Lai, Philip H., Bootwalla, Moiz S., Van Den Berg, David J., Triche, Timothy, Jr., Baylin, Stephen B., Laird, Peter W., Rosenberg, Mara ORCID: 0000-0001-6400-3161, Chin, Lynda, Zhang, Jianhua, Cho, Juok, DiCara, Daniel, Heiman, David ORCID: 0000-0001-7895-4259, Lin, Pei, Mallard, William, Voet, Douglas, Zhang, Hailei, Zou, Lihua, Noble, Michael S., Lawrence, Michael S., Saksena, Gordon, Gehlenborg, Nils ORCID: 0000-0003-0327-8297, Thorvaldsdottir, Helga, Mesirov, Jill, Nazaire, Marc-Danie, Robinson, Jim, Getz, Gad, Lee, William ORCID: 0000-0001-9582-4413, Aksoy, B. Arman, Ciriello, Giovanni ORCID: 0000-0003-2021-8683, Taylor, Barry S., Dresdner, Gideon, Gao, Jianjiong, Gross, Benjamin, Seshan, Venkatraman E., Ladanyi, Marc, Reva, Boris, Sinha, Rileen ORCID: 0000-0001-5497-5055, Sumer, S. Onur, Weinhold, Nils, Schultz, Nikolaus ORCID: 0000-0002-0131-4904, Shen, Ronglai, Sander, Chris, Ma, Singer, Zhu, Jingchun, Radenbaugh, Amie, Stuart, Joshua M., Benz, Christopher C., Yau, Christina, Haussler, David, Spellman, Paul T., Wilkerson, Matthew D., Parker, Joel S., Hoadley, Katherine A., Kimes, Patrick K., Hayes, D. Neil, Perou, Charles M., Broom, Bradley M., Wang, Jing, Lu, Yiling, Diao, Lixia, Byers, Lauren Averett, Liu, Wenbin, Heymach, John V., Amos, Christopher I., Weinstein, John N., Akbani, Rehan, Mills, Gordon B., Curley, Erin, Paulauskis, Joseph, Lau, Kevin, Morris, Scott, Shelton, Troy, Mallery, David, Gardner, Johanna, Penny, Robert, Saller, Charles, Tarvin, Katherine, Richards, William G., Cerfolio, Robert, Bryant, Ayesha ORCID: 0000-0002-3704-0319, Raymond, Daniel P., Pennell, Nathan A., Farver, Carol, Czerwinski, Christine, Huelsenbeck-Dill, Lori, Iacocca, Mary, Petrelli, Nicholas, Rabeno, Brenda, Brown, Jennifer, Bauer, Thomas, Dolzhanskiy, Oleg, Potapova, Olga, Rotin, Daniil ORCID: 0000-0003-3386-0077, Voronina, Olga, Nemirovich-Danchenko, Elena, Fedosenko, Konstantin V., Gal, Anthony, Behera, Madhusmita, Ramalingam, Suresh S., Sica, Gabriel, Flieder, Douglas, Boyd, Jeff, Weaver, JoEllen, Kohl, Bernard, Sandusky, George, Juhl, Hartmut, Duhig, Edwina, Illei, Peter, Gabrielson, Edward, Shin, James, Lee, Beverly, Rogers, Kristen, Trusty, Dante, Brock, Malcolm V., Williamson, Christina, Burks, Eric ORCID: 0000-0002-3122-2875, Rieger-Christ, Kimberly, Holway, Antonia, Sullivan, Travis, Wigle, Dennis A., Asiedu, Michael K., Kosari, Farhad, Travis, William D., Rekhtman, Natasha, Zakowski, Maureen, Rusch, Valerie W., Zippile, Paul, Suh, James, Pass, Harvey, Goparaju, Chandra, Owusu-Sarpong, Yvonne, Bartlett, John M. S., Kodeeswaran, Sugy, Parfitt, Jeremy, Sekhon, Harmanjatinder, Albert, Monique, Eckman, John, Myers, Jerome B., Cheney, Richard, Morrison, Carl, Gaudioso, Carmelo, Borgia, Jeffrey A., Bonomi, Philip, Pool, Mark, Liptay, Michael J., Moiseenko, Fedor, Zaytseva, Irina, Dienemann, Hendrik, Meister, Michael, Schnabel, Philipp A., Muley, Thomas R., Peifer, Martin ORCID: 0000-0002-5243-5503, Gomez-Fernandez, Carmen, Herbert, Lynn, Egea, Sophie, Huang, Mei, Thorne, Leigh B., Boice, Lori, Salazar, Ashley Hill, Funkhouser, William K., Rathmell, W. Kimryn, Dhir, Rajiv, Yousem, Samuel A., Dacic, Sanja, Schneider, Frank, Siegfried, Jill M., Hajek, Richard, Watson, Mark A., McDonald, Sandra, Meyers, Bryan, Clarke, Belinda, Yang, Ian A., Fong, Kwun M., Hunter, Lindy, Windsor, Morgan, Bowman, Rayleen V., Peters, Solange, Letovanec, Igor, Khan, Khurram Z., Jensen, Mark A., Snyder, Eric E., Srinivasan, Deepak, Kahn, Ari B., Baboud, Julien, Pot, David A., Shaw, Kenna R. Mills, Sheth, Margi, Davidsen, Tanja, Demchok, John A., Yang, Liming, Wang, Zhining, Tarnuzzer, Roy ORCID: 0000-0002-3725-4173, Zenklusen, Jean Claude, Ozenberger, Bradley A., Sofia, Heidi J., Travis, William D., Cheney, Richard, Clarke, Belinda, Dacic, Sanja, Duhig, Edwina, Funkhouser, William K., Illei, Peter, Farver, Carol, Rekhtman, Natasha, Sica, Gabriel, Suh, James and Tsao, Ming-Sound
(2014).
Comprehensive molecular profiling of lung adenocarcinoma.
Nature, 511 (7511).
S. 543 - 551.
LONDON:
NATURE PUBLISHING GROUP.
ISSN 1476-4687
Full text not available from this repository.
Abstract
Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. High rates of somatic mutation were seen(mean 8.9 mutations per megabase). Eighteen genes were statistically significantly mutated, including RIT1 activating mutations and newly described loss-of-function MGA mutations which are mutually exclusive with focal MYC amplification. EGFR mutations were more frequent in female patients, whereas mutations in RBM10 were more common in males. Aberrations in NF1, MET, ERBB2 and RIT1 occurred in 13% of cases and were enriched in samples otherwise lacking an activated oncogene, suggesting a driver role for these events in certain tumours. DNA and mRNA sequence from the same tumour highlighted splicing alterations driven by somatic genomic changes, including exon 14 skipping in MET mRNA in 4% of cases. MAPK and PI(3)K pathway activity, when measured at the protein level, was explained by known mutations in only a fraction of cases, suggesting additional, unexplained mechanisms of pathway activation. These data establish a foundation for classification and further investigations of lung adenocarcinoma molecular pathogenesis.
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Journal Article
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| Creators: |
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| Collisson, Eric A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Campbell, Joshua D. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Brooks, Angela N. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Berger, Alice H. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Lee, William | UNSPECIFIED | orcid.org/0000-0001-9582-4413 | UNSPECIFIED | | Chmielecki, Juliann | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Beer, David G. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Cope, Leslie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Creighton, Chad J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Danilova, Ludmila | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Ding, Li | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Getz, Gad | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Hammerman, Peter S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Hayes, D. Neil | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Hernandez, Bryan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Herman, James G. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Heymach, John V. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Jurisica, Igor | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Kucherlapati, Raju | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Kwiatkowski, David | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Ladanyi, Marc | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Robertson, Gordon | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Schultz, Nikolaus | UNSPECIFIED | orcid.org/0000-0002-0131-4904 | UNSPECIFIED | | Shen, Ronglai | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Sinha, Rileen | UNSPECIFIED | orcid.org/0000-0001-5497-5055 | UNSPECIFIED | | Sougnez, Carrie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Tsao, Ming-Sound | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Travis, William D. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Weinstein, John N. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Wigle, Dennis A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Wilkerson, Matthew D. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Chu, Andy | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Cherniack, Andrew D. | UNSPECIFIED | orcid.org/0000-0003-0470-0111 | UNSPECIFIED | | Hadjipanayis, Angela | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Rosenberg, Mara | UNSPECIFIED | orcid.org/0000-0001-6400-3161 | UNSPECIFIED | | Weisenberger, Daniel J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Laird, Peter W. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Radenbaugh, Amie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Ma, Singer | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Stuart, Joshua M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Byers, Lauren Averett | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Baylin, Stephen B. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Govindan, Ramaswamy | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Meyerson, Matthew | UNSPECIFIED | orcid.org/0000-0002-9133-8108 | UNSPECIFIED | | Rosenberg, Mara | UNSPECIFIED | orcid.org/0000-0001-6400-3161 | UNSPECIFIED | | Gabriel, Stacey B. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Cibulskis, Kristian | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Sougnez, Carrie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Kim, Jaegil | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Stewart, Chip | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Lichtenstein, Lee | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Lander, Eric S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Lawrence, Michael S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Kandoth, Cyriac | UNSPECIFIED | orcid.org/0000-0002-1345-3573 | UNSPECIFIED | | Fulton, Robert | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Fulton, Lucinda L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | McLellan, Michael D. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Wilson, Richard K. | UNSPECIFIED | orcid.org/0000-0002-1992-1358 | UNSPECIFIED | | Ye, Kai | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Fronick, Catrina C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Maher, Christopher A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Miller, Christopher A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Wendl, Michael C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Cabanski, Christopher | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Ding, Li | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Mardis, Elaine | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Govindan, Ramaswamy | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Creighton, Chad J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Wheeler, David | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Balasundaram, Miruna | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Butterfield, Yaron S. N. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Carlsen, Rebecca | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Chu, Andy | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Chuah, Eric | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Dhalla, Noreen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Guin, Ranabir | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Hirst, Carrie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Lee, Darlene | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Li, Haiyan I. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Mayo, Michael | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Moore, Richard A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Mungall, Andrew J. | UNSPECIFIED | orcid.org/0000-0002-0905-2742 | UNSPECIFIED | | Schein, Jacqueline E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Sipahimalani, Payal | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Tam, Angela | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Varhol, Richard | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Robertson, A. Gordon | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Wye, Natasja | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Thiessen, Nina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Holt, Robert A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Jones, Steven J. M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Marra, Marco A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Campbell, Joshua D. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Brooks, Angela N. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Chmielecki, Juliann | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Imielinski, Marcin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Onofrio, Robert C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Hodis, Eran | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Zack, Travis | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Sougnez, Carrie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Helman, Elena | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Pedamallu, Chandra Sekhar | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Mesirov, Jill | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Cherniack, Andrew D. | UNSPECIFIED | orcid.org/0000-0003-0470-0111 | UNSPECIFIED | | Saksena, Gordon | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Schumacher, Steven E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Carter, Scott L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Hernandez, Bryan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Garraway, Levi | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Beroukhim, Rameen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Gabriel, Stacey B. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Getz, Gad | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Meyerson, Matthew | UNSPECIFIED | orcid.org/0000-0002-9133-8108 | UNSPECIFIED | | Hadjipanayis, Angela | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Lee, Semin | UNSPECIFIED | orcid.org/0000-0002-9015-6046 | UNSPECIFIED | | Mahadeshwar, Harshad S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Pantazi, Angeliki | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Protopopov, Alexei | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Ren, Xiaojia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Seth, Sahil | UNSPECIFIED | orcid.org/0000-0003-4579-3959 | UNSPECIFIED | | Song, Xingzhi | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Tang, Jiabin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Yang, Lixing | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Zhang, Jianhua | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Chen, Peng-Chieh | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Parfenov, Michael | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Xu, Andrew Wei | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Santoso, Netty | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Chin, Lynda | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Park, Peter J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Kucherlapati, Raju | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Hoadley, Katherine A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Auman, J. Todd | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Meng, Shaowu | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Shi, Yan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Buda, Elizabeth | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Waring, Scot | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Veluvolu, Umadevi | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Tan, Donghui | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Mieczkowski, Piotr A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Jones, Corbin D. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Simons, Janae V. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Soloway, Matthew G. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Bodenheimer, Tom | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Jefferys, Stuart R. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Roach, Jeffrey | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Hoyle, Alan P. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Wu, Junyuan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Balu, Saianand | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Singh, Darshan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Prins, Jan F. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | | Marron, J. 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|
| URN: |
urn:nbn:de:hbz:38-433634 |
| DOI: |
10.1038/nature13385 |
| Journal or Publication Title: |
Nature |
| Volume: |
511 |
| Number: |
7511 |
| Page Range: |
S. 543 - 551 |
| Date: |
2014 |
| Publisher: |
NATURE PUBLISHING GROUP |
| Place of Publication: |
LONDON |
| ISSN: |
1476-4687 |
| Language: |
English |
| Faculty: |
Unspecified |
| Divisions: |
Unspecified |
| Subjects: |
no entry |
| Uncontrolled Keywords: |
| Keywords | Language |
|---|
| CANCER GENOME; CELL-LINES; MUTATIONS; EXPRESSION; GENE; REVEALS; CLASSIFICATION; INACTIVATION; LANDSCAPE; DISCOVERY | Multiple languages | | Multidisciplinary Sciences | Multiple languages |
|
| URI: |
http://kups.ub.uni-koeln.de/id/eprint/43363 |
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